MELASMA
Clinical trials for MELASMA explained in plain language.
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New cream trio aims to outshine standard melasma treatment
Disease control CompletedThis study compares a new combination cream (containing isobutylamido-thiazolyl-resorcinol, retinoic acid, and dexamethasone) to the standard Kligman's formula for treating melasma, a common skin condition causing dark patches. The trial enrolls 56 women aged 16–60 who apply the …
Matched conditions: MELASMA
Phase: PHASE4 • Sponsor: Ghurki Trust and Teaching Hospital • Aim: Disease control
Last updated Jul 02, 2026 00:00 UTC
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New needle treatment may fade melasma in darker skin
Disease control CompletedThis study tested whether radiofrequency microneedling can safely treat melasma in people with darker skin tones (Fitzpatrick types IV-VI). Ten adults with melasma received the treatment, and doctors measured changes in severity using a standard scoring system. The goal was to se…
Matched conditions: MELASMA
Phase: NA • Sponsor: The Cleveland Clinic • Aim: Disease control
Last updated Jun 27, 2026 09:03 UTC
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Stem cell exosomes plus laser shows promise for stubborn melasma
Disease control CompletedThis study tested a new treatment for melasma, a stubborn skin condition causing dark patches on the face. Researchers combined stem cell exosomes (tiny particles from umbilical cord cells) with a special laser in 30 adults. The goal was to see if this combo is safe and works bet…
Matched conditions: MELASMA
Phase: NA • Sponsor: Fujian Medical University Union Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:12 UTC
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Cream showdown: which works better for dark spots?
Disease control CompletedThis study tested two creams—20% azelaic acid and 4% hydroquinone—on 146 adults with melasma, a condition causing dark patches on the face. Participants applied the cream daily for 12 weeks, and doctors tracked changes in patch size and color. The goal was to see which cream work…
Matched conditions: MELASMA
Phase: NA • Sponsor: Gujranwala medical college District Headquarters Hospital, Gujranwala • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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Melasma treatment showdown: needle or pill?
Disease control CompletedThis completed study in Pakistan compared two ways of giving tranexamic acid for melasma: tiny skin injections versus pills. 218 adults with melasma took part. Researchers measured changes in the Melasma Area and Severity Index after 8 weeks to see which method worked better.
Matched conditions: MELASMA
Phase: EARLY_PHASE1 • Sponsor: Hayat Abad Medical Complex, Peshawar • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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New serums take on hydroquinone in skin brightening showdown
Symptom relief CompletedThis 4-week pilot study tested two brightening serums against 4% hydroquinone in 18 adults with hyperpigmentation or melasma. Each participant used different products on each side of their face to compare results. The goal was to see if the serums could improve skin tone evenness…
Matched conditions: MELASMA
Phase: NA • Sponsor: Revision Skincare • Aim: Symptom relief
Last updated Jun 27, 2026 13:06 UTC
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Could a diabetes drug gel fade melasma? small study pits metformin against standard cream
Symptom relief CompletedThis study tested whether a 30% metformin gel applied nightly can reduce melasma (dark patches on the face) as well as a standard triple cream containing hydroquinone, tretinoin, and a steroid. Thirty-four adults with melasma used one of the two treatments plus sunscreen for 12 w…
Matched conditions: MELASMA
Phase: NA • Sponsor: Jinnah Postgraduate Medical Centre • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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Screen time and skin spots: new study investigates blue Light's effect on melasma
Knowledge-focused CompletedThis study looked at whether blue light from computer and TV screens can make melasma (a common skin condition causing dark patches on the face) worse. Twelve women with melasma had one side of their face exposed to blue light for 30 minutes a day over 5 days, while the other sid…
Matched conditions: MELASMA
Phase: NA • Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC