Can a two-acid cream fade stubborn melasma?
NCT ID NCT07727954
First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time
Summary
This trial tests whether a cream containing azelaic acid and tranexamic acid can reduce the dark patches of melasma better than a placebo. Adults with facial melasma will apply the cream daily for four weeks. Researchers will measure changes in pigmentation, quality of life, and any side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a topical cream containing 12% azelaic acid and 5% tranexamic acid
- What this could lead to
- If effective, this cream could offer a new, non-invasive option for reducing melasma pigmentation and improving quality of life.
- What could go wrong
- This is a small, short-term trial (40 people, 4 weeks). Results may not apply to all skin types, and the cream may cause skin irritation or not outperform placebo.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The Skin Place
Tijuana, Estado de Baja California, 22010, Mexico
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Skin pigment battle: which melasma treatment wins?