MALIGNANT PLEURAL MESOTHELIOMA

This study tested a new drug called PM8002, which targets two proteins that help cancer grow, combined with standard chemotherapy. It involved 31 adults with a rare cancer called malignant mesothelioma that could not be removed by surgery. The goal was to see if the combination s…

This phase 3 trial tested a new approach for malignant pleural mesothelioma, a rare and aggressive cancer of the lung lining. Researchers gave 53 patients a gene therapy (rAd-IFN) injected into the chest cavity, along with the drugs celecoxib and gemcitabine. The goal was to see …

This study looked at whether a short, intense course of chest radiation given just before surgery can kill cancer cells and prevent them from spreading outside the chest during the operation. It involved 104 people with malignant pleural mesothelioma, a cancer linked to asbestos.…

This pilot study tested whether adding intrapleural photodynamic therapy (PDT) to standard surgery and chemotherapy is safe and feasible for patients with malignant pleural mesothelioma. Six participants received a light-sensitive drug followed by laser light inside the chest cav…

This study tested whether a combination of two immunotherapy drugs (nivolumab and ipilimumab) works better than standard chemotherapy for Chinese patients with advanced pleural mesothelioma, a rare cancer of the lung lining. 102 patients who could not have surgery were randomly a…

This study tested whether adding the immunotherapy drug durvalumab to standard chemotherapy helps people with advanced pleural mesothelioma live longer. The trial included 214 adults whose cancer could not be removed by surgery. Participants received either the combination or a s…

This study tested an experimental drug called RC88 in 198 people with advanced solid tumors that had stopped responding to standard treatments. The goal was to find a safe dose and see if the drug could shrink tumors or slow their growth. The study was completed and looked at sid…

This study tested a new way to deliver chemotherapy directly to the tumor in adults with malignant pleural mesothelioma that cannot be removed by surgery. The treatment, called transarterial chemoperfusion, uses a combination of three drugs (cisplatin, methotrexate, and gemcitabi…

This early-phase trial tested a new treatment called CTX131 for adults with advanced solid tumors that have not responded to standard therapies. The treatment uses donor immune cells that are gene-edited to target a protein called CD70 found on cancer cells. The study enrolled 19…

This study looks back at 204 patients with untreated, inoperable malignant pleural mesothelioma who received a combination of two immunotherapy drugs, nivolumab and ipilimumab, through an early access program in France. Researchers will collect data from medical records to see ho…