LOCALLY ADVANCED RECTAL CANCER
Clinical trials for LOCALLY ADVANCED RECTAL CANCER explained in plain language.
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Can a short burst of radiation plus triple chemotherapy wipe out rectal cancer before surgery?
⭐️ CURE ⭐️ OngoingThis phase 2 trial is testing whether a short course of radiation followed by a powerful three-drug chemotherapy regimen (FOLFOXIRI) can completely eliminate tumors in people with locally advanced rectal cancer before they undergo surgery. The study enrolls adults aged 18 to 70 w…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER
Phase: PHASE2 • Sponsor: Gruppo Oncologico del Nord-Ovest • Aim: ⭐️ CURE ⭐️
Last updated Jul 26, 2026 00:00 UTC
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Can a targeted radiation combo boost rectal cancer remission?
Disease control TerminatedThis trial is testing whether a more focused radiation field, combined with chemotherapy and an immunotherapy drug called camrelizumab, can improve outcomes for people with a certain type of locally advanced rectal cancer. The study will compare this new approach to a standard tr…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER
Phase: PHASE2 • Sponsor: Hebei Medical University Fourth Hospital • Aim: Disease control
Last updated Aug 02, 2026 00:00 UTC
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Timing of chemo may boost rectal cancer remission
Disease control OngoingThis trial tests whether giving chemotherapy before or after radiation therapy works better for people with locally advanced rectal cancer that has a high risk of coming back. Participants receive the same drugs (capecitabine and oxaliplatin) but in a different order. The goal is…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER
Phase: PHASE2 • Sponsor: Institute of Oncology Ljubljana • Aim: Disease control
Last updated Jul 11, 2026 00:00 UTC
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Immune-boosting combo aims to wipe out rectal cancer before surgery
Disease control OngoingThis study tests whether adding an immunotherapy drug (tislelizumab) to standard chemoradiation before surgery can improve outcomes for people with locally advanced rectal cancer. About 100 participants will receive the combination treatment, and researchers will measure how many…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER
Phase: PHASE2 • Sponsor: Peking Union Medical College Hospital • Aim: Disease control
Last updated Jul 09, 2026 00:00 UTC
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Could chemo replace surgery for rectal cancer? new study explores
Disease control OngoingThis study tests whether a combination of chemotherapy (FOLFOX) and a short course of radiation can eliminate advanced rectal cancer without needing surgery. 12 adults with locally advanced rectal cancer are being watched closely after treatment to see if the cancer fully respond…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER
Phase: PHASE2 • Sponsor: University of Rochester • Aim: Disease control
Last updated Jun 27, 2026 13:02 UTC
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Could one drug replace the standard triple therapy for rectal cancer?
Disease control OngoingThis study tests whether a single immunotherapy drug, dostarlimab, can effectively treat people with a specific type of advanced rectal cancer (dMMR/MSI-H) that has not been treated before. About 154 participants will receive the drug and, if their cancer completely disappears, t…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER
Phase: PHASE2 • Sponsor: GlaxoSmithKline • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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Zapping cancer during surgery: new rectal cancer trial underway
Disease control OngoingThis study tests whether giving a single dose of radiation directly to the tumor area during surgery is feasible for people with advanced or recurrent rectal cancer. About 31 participants will be randomly assigned to receive standard surgery, surgery plus a standard radiation dos…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER
Phase: NA • Sponsor: University Hospital Southampton NHS Foundation Trust • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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Could a plant extract make rectal cancer treatment easier to tolerate?
Symptom relief OngoingThis study tests whether adding chlorophyllin, a natural plant extract, to standard chemoradiation can reduce side effects like diarrhea, bladder irritation, and low blood counts in people with locally advanced rectal cancer. About 76 adults will receive either chlorophyllin or a…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER
Phase: PHASE2 • Sponsor: Tata Memorial Centre • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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New study aims to predict who can skip surgery for rectal cancer
Knowledge-focused OngoingThis pilot study is testing whether regular MRI scans and blood tests can accurately track how rectal cancer responds to pre-surgery treatment. The goal is to develop a way to predict complete remission without needing surgery. Forty adults with locally advanced rectal cancer wil…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER
Sponsor: Jena University Hospital • Aim: Knowledge-focused
Last updated Aug 08, 2026 00:03 UTC
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Exercise before and during radiotherapy: a new hope for rectal cancer?
Knowledge-focused TerminatedThis study planned to test if a 7-week program of aerobic and resistance exercise is feasible for people with locally advanced rectal cancer undergoing short-course radiotherapy. It aimed to recruit 30 patients and track how many joined, attended sessions, and stayed in the study…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER
Phase: NA • Sponsor: University of Hull • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:11 UTC