LOCALLY ADVANCED RECTAL CANCER
Clinical trials for LOCALLY ADVANCED RECTAL CANCER explained in plain language.
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New combo without chemotherapy aims to shrink rectal tumors before surgery
Disease control Not yet recruitingThis small study tests a new approach for people with stage II/III rectal cancer that has not spread. Instead of chemotherapy, patients receive targeted internal radiation followed by two doses of the immunotherapy drug nivolumab before surgery. The goal is to see if this combina…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER
Phase: PHASE2 • Sponsor: Dr. Te Vuong • Aim: Disease control
Last updated Jun 27, 2026 13:08 UTC
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Oxygen-Boosting injection may help rectal cancer patients avoid surgery
Disease control Not yet recruitingThis study tests whether injecting a special solution (KRC-01) into rectal tumors before radiation can make the radiation work better. The solution increases oxygen inside the tumor, which helps radiation kill cancer cells. About 24 adults with advanced rectal cancer that hasn't …
Matched conditions: LOCALLY ADVANCED RECTAL CANCER
Phase: PHASE2 • Sponsor: Gustave Roussy, Cancer Campus, Grand Paris • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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Triple chemo may help rectal cancer patients avoid surgery
Disease control Not yet recruitingThis Phase 3 trial tests whether a three-drug chemotherapy combination (FOLFOXIRI) works better than the standard two-drug combination (CAPOX/FOLFOX) for people with high-risk locally advanced rectal cancer. Both groups also receive chemoradiation, and then either surgery or a wa…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER
Phase: PHASE3 • Sponsor: J. W. A. Burger • Aim: Disease control
Last updated Jun 27, 2026 11:01 UTC
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Shorter radiation combo may boost rectal cancer remission
Disease control Not yet recruitingThis study compares two treatments for locally advanced rectal cancer: a shorter course of radiation plus chemotherapy (CAPOX) and immunotherapy (tislelizumab) versus a longer course of chemoradiation plus the same immunotherapy. The goal is to see which approach leads to a highe…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER
Phase: PHASE2 • Sponsor: Fujian Cancer Hospital • Aim: Disease control
Last updated Jun 27, 2026 11:01 UTC
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AI reads scans to spot hidden cancer spread
Diagnosis Not yet recruitingThis study tests an AI-powered 3D imaging model to improve detection of cancer spread in patients with stage II-III rectal cancer. Researchers will analyze existing CT and MRI scans from 1,500 patients to see if the AI can predict whether the cancer has reached the edge of the ti…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER
Sponsor: Taichung Veterans General Hospital • Aim: Diagnosis
Last updated Jun 26, 2026 18:58 UTC
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Pumping iron against cancer: exercise may ease treatment side effects
Symptom relief Not yet recruitingThis study tests whether a supervised strength-training program is safe and practical for people with locally advanced rectal cancer who are receiving chemotherapy and radiation before surgery. Fifteen participants will do personalized resistance exercises twice a week for about …
Matched conditions: LOCALLY ADVANCED RECTAL CANCER
Phase: NA • Sponsor: Fundacion Arturo Lopez Perez • Aim: Symptom relief
Last updated Jun 27, 2026 09:11 UTC
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Turmeric power: could curcumin ease chemo side effects for rectal cancer patients?
Symptom relief Not yet recruitingThis study tests a highly absorbable form of curcumin (from turmeric) in 72 adults with mid-to-low rectal cancer who are getting chemoradiation before surgery. The goal is to see if curcumin can reduce severe gut side effects like diarrhea and rectal pain. Researchers will also c…
Matched conditions: LOCALLY ADVANCED RECTAL CANCER
Phase: PHASE2 • Sponsor: Chang Gung Memorial Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 07:59 UTC