INSULIN SENSITIVITY

This Phase 1 study tests retatrutide, a new injectable drug, in 95 adults with type 2 diabetes who already take metformin. The goal is to see if retatrutide improves insulin sensitivity and beta-cell function better than placebo or semaglutide over 28 weeks. Participants will rec…

This study looks at whether time-restricted eating (eating only during certain hours) can improve blood pressure and insulin sensitivity in people who work night shifts. Night shift workers are at higher risk for heart disease and type 2 diabetes. Researchers will compare 4 weeks…

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG) can help people with obesity and a serious liver condition called MASH. ESG reduces stomach size by about 70% using an endoscope, leading to significant weight loss. Researchers wi…

This study tests whether colchicine, a drug used for gout, can improve how the body uses insulin in people with type 1 diabetes who have low-grade inflammation. 26 adults will receive either colchicine or a placebo for four weeks, and their insulin sensitivity will be measured us…

This study compares stevia-sweetened drinks, sugary drinks, and flavored water in children ages 8-12 who regularly drink sugary beverages. Over 8 to 14 weeks, researchers will measure changes in weight, body fat, insulin resistance, blood fats, and blood pressure. The goal is to …

This study is testing whether giving insulin through a vein every five minutes for two hours, once a week for six months, can improve how the body uses sugar and how well people with Alzheimer's think. Eight adults with mild to moderate Alzheimer's will take part. The goal is to …

This study looks at whether the artificial sweeteners aspartame and sucralose change how the body handles sugar in older adults with prediabetes. Researchers will give participants either one of the sweeteners or a placebo for several weeks and track blood sugar levels continuous…

This study looks at how weight loss changes the fat stored inside muscles, called IMAT, in people with obesity. Researchers want to see if losing weight reduces harmful signals from this fat that can lead to insulin resistance and muscle weakness. Seventy participants will follow…

This study looks at how a single session of leg exercise improves the way muscles respond to insulin in 8 healthy young men aged 22-35. Researchers will measure glucose uptake and analyze muscle tissue to understand the early signals that boost insulin sensitivity. The goal is to…

This study looks at how losing 10% of your body weight with or without exercise affects your fat tissue and overall health. Researchers want to see if adding exercise leads to lasting benefits, even if some weight is regained. The study involves 68 adults with obesity who will ei…