INSULIN SENSITIVITY

This study tests whether a minimally invasive stomach-shrinking procedure (endoscopic sleeve gastroplasty) combined with lifestyle changes is better than lifestyle changes alone for treating a serious liver condition called MASH in people with obesity. The procedure reduces stoma…

This study tests whether colchicine, an anti-inflammatory drug, can improve how well the body responds to insulin in people with type 1 diabetes who have low-grade inflammation. About 26 adults will receive either colchicine or a placebo for a period, and their insulin sensitivit…

This study tests whether giving insulin once a week for up to 2 hours can improve how the body uses insulin and how well people with Alzheimer's think. Eight adults with mild to moderate Alzheimer's will receive the treatment for 6 months and take memory tests. The goal is to see…

This study looks at how losing weight affects the fat stored inside your muscles, which is linked to insulin resistance and muscle weakness. Researchers will measure body fat, muscle strength, and take small muscle samples before and after a 12-week diet plan. The goal is to unde…

This study looks at how adding exercise to a weight loss program changes belly fat and improves health. Researchers will compare people who only cut calories with those who also exercise. The goal is to understand why exercise provides extra health benefits, even if some weight i…

This study looks at whether two common artificial sweeteners, aspartame and sucralose, change how the body handles blood sugar in adults aged 40 and older who have prediabetes. Researchers will provide all meals for 8 weeks and track blood sugar levels continuously. The goal is t…