HNSCC

This is an early-stage study to test the safety and initial effectiveness of a new drug called RO7502175 for people with advanced solid tumors that have spread or cannot be cured. The drug will be tested both by itself and combined with other approved cancer drugs. The main goals…

This early-stage study is testing whether an experimental drug called NRM-823 is safe and can help control advanced cancers that have stopped responding to standard treatments. Researchers will give NRM-823 alone and combined with immunotherapy to about 150 adults with various so…

This is a very early-stage study to test the safety of a new drug called GV20-0251 in adults with advanced solid tumors that have progressed despite standard treatments. The main goal is to find a safe dose by giving the drug to small groups of patients at different levels. It is…

This is a very early, first-in-human study to test the safety and find the right dose of a new radioactive drug called 177Lu-RAD204. It is for adults with advanced solid tumors (like lung, breast, or skin cancer) that have spread and have stopped responding to standard treatments…

This is a very early study to check the safety and find the right dose of a new injection called TI-0093. It is for people with advanced head, neck, or cervical cancers linked to HPV-16 that have come back or spread after standard treatments. The main goals are to see what side e…

This early-stage study is testing the safety and early effectiveness of an experimental cancer treatment called T3011. The treatment is injected directly into tumors and is being tested both alone and combined with an existing immunotherapy drug (pembrolizumab) in people with adv…

This is the first study in people to test a new experimental cancer drug called ALX2004. It aims to find a safe dose and see if the drug can help control advanced cancers that have spread and stopped responding to other treatments. The trial will enroll about 170 adults with spec…

This early study is testing a new, personalized treatment for people with advanced head and neck cancer that has come back or spread. Doctors take a patient's own immune cells from a tumor, grow billions of them in a lab, and infuse them back along with a standard immunotherapy d…

This study is testing whether adding an experimental drug called DCSZ11 to standard cancer treatments is safe and effective for people with advanced solid tumors that have spread. Researchers will enroll 9 adult patients with specific types of cancer to see how well the combinati…

This study is testing whether adding a new drug called HCB101 to an existing immunotherapy (pembrolizumab) can help control advanced head and neck cancer that has stopped responding to standard platinum-based chemotherapy. The trial will enroll about 50 adults to first find the s…

This is a first-in-human study to test the safety and find the right dose of a new oral drug, OKN4395, for people with advanced solid tumors. The trial will give the drug alone and combined with an existing immunotherapy (pembrolizumab) to about 166 participants with cancers like…

This is the first-ever study in people for a new drug called EPI-326. It aims to find a safe dose and see how the body handles the drug in patients with advanced lung cancer (with a specific genetic change called EGFR mutation) or advanced head and neck cancer. The main goal is t…

This study is testing if combining immunotherapy drugs (called PD-1/PD-L1 inhibitors) with targeted radiation is more effective for controlling several advanced cancers, including lung and head/neck cancers. It aims to help patients live longer and also tries to find patterns in …

This is an early-stage study to find a safe dose of an experimental therapy called MQ710 for people with advanced solid tumors that have returned, spread, or stopped responding to standard treatments. The therapy is a modified virus designed to be injected directly into tumors. R…

This early-stage study is testing if adding two immunotherapy drugs (cemiplimab and cetuximab) to standard chemotherapy before surgery is safe for people with advanced head and neck cancer. The main goal is to see if this stronger pre-surgery treatment can work well enough that p…

This study is testing a new drug called TUB-030 in adults with advanced solid cancers that have not responded to other treatments. The main goals are to find the safest dose and see if the drug helps control the cancer. It will focus on specific cancers like head and neck cancer …

This study is testing a new type of cell therapy called A2B395 for adults with advanced solid tumors that have spread or returned. The therapy uses modified immune cells designed to specifically kill cancer cells while protecting the patient's healthy cells. The main goals are to…

This study is testing an experimental drug called YL202 in people with advanced solid tumors that have spread or can't be removed by surgery. The trial aims to see if YL202 can shrink tumors and control cancer growth while monitoring side effects. It will enroll 200 adults in Chi…

This early-stage study is testing whether directly injecting an experimental treatment called VLPONC-01 into head and neck tumors is safe and can help shrink them. Researchers are enrolling 41 patients with advanced or surgically removable cancers to receive the injections, somet…

This study is testing a new high-resolution PET-CT scanner designed to help surgeons see cancer margins during surgery. After a tumor is removed, the device scans it in the operating room to check if all cancerous tissue was taken out. The goal is to see if this real-time imaging…

This early study is testing a new approach to help surgeons see head and neck cancer cells during an operation. Researchers are combining an approved cancer drug with a special fluorescent dye. The goal is to see if this combination makes cancer cells glow under a special camera,…