HEMATOLOGICAL MALIGNANCIES

This study is for older adults getting a stem cell transplant for blood cancers. It compares two different doses of a key drug (cyclophosphamide) used to prevent a serious complication called graft-versus-host disease (GVHD). The main goal is to see if a lower dose helps patients…

This study is testing a new drug called talquetamab for people with multiple myeloma, a type of blood cancer, that has returned or is no longer responding to other treatments. The main goals are to see if the drug is effective at controlling the cancer and to check how safe it is…

This is the first study in people to test a new drug called ICP-248, given alone or with another cancer drug, for adults with certain relapsed or hard-to-treat B-cell blood cancers. The main goals are to find a safe dose, see how the body processes the drug, and get an early look…

This is the first study in people for an experimental oral drug called HMPL-506. Its main goals are to find a safe dose and see how the body processes the drug in adults with advanced blood cancers that have returned or not responded to prior treatments. The study will also look …

This is the first human trial testing an experimental drug called DS3790a for people with various blood cancers. The study aims to find safe doses and see if the drug, given alone or with other treatments, can help control these cancers. Researchers will enroll 420 adults with bl…

This study will follow patients for 15 years after they received a Galapagos CAR T-cell therapy for blood cancers. The goal is to monitor for any long-term side effects and see how well the treatment continues to work over time. It will include about 546 people who have already r…

This study is testing a new program where nurses start conversations about palliative care early in a child's cancer treatment. It aims to see if these regular talks improve the child's quality of life, manage symptoms better, and reduce stress for family caregivers compared to s…

This study aims to understand why some early, non-symptomatic blood conditions turn into cancer. Researchers will observe 10,000 adults who have these early conditions or a history of cancer. They will analyze genetic material from routine blood and tissue samples to identify cha…