GERM CELL TUMOR

This study tests a combination of two chemotherapy drugs, teniposide and cisplatin, in 40 people newly diagnosed with a rare type of brain tumor called central malignant germ cell tumor. The main goal is to see how well the drugs shrink tumors and to monitor safety. Researchers a…

This early-stage study tests a new drug called ZW251 in about 100 people with advanced liver cancer, a type of lung cancer, or germ cell tumors. The drug is designed to seek out and attack cancer cells while sparing healthy ones. The main goals are to check safety and find the ri…

This study looks at two groups of people with germ cell tumors. For those with low-risk tumors that haven't spread, doctors will monitor them closely after surgery instead of giving chemotherapy. For standard-risk tumors that have spread, the study compares two chemotherapy drugs…

This early-phase study tests whether a new type of immune cell therapy, called CAR T cells, can be safely given directly into the brain or spinal fluid of children and young adults with certain aggressive brain tumors. The therapy uses the patient's own immune cells, which are mo…

This early-phase study tests a four-drug combination (vorinostat plus three chemotherapy drugs) in children, teens, and young adults up to age 30 whose solid tumors or brain cancers have returned or not responded to standard treatment. The main goal is to find a safe dose and und…

This study tests whether taking two drugs (zanzalintinib and oral etoposide) after high-dose chemotherapy can help prevent cancer from growing back in people with relapsed germ cell tumors. About 38 adults whose cancer has not been cured by standard treatments will participate. T…

This study is for people with relapsed germ cell tumors (a type of cancer often in the testicles or ovaries) who have already had high-dose chemotherapy and a stem cell transplant. It tests whether taking a daily oral chemotherapy drug called etoposide for a while after treatment…

This early-stage study tests a new drug called XmAb541 in people with advanced ovarian, endometrial, or germ cell tumors that have not responded to other treatments. The main goal is to see if the drug is safe and find the best dose. About 282 adults will take part, and researche…

This study is testing whether a safe green dye, called indocyanine green (ICG), can help surgeons see if a child's cancer has spread to nearby lymph nodes. About 10 children with solid tumors will get the dye injected during surgery. The goal is to see if the dye makes the lymph …

This study is testing a new, robot-assisted technique that uses a special dye to find if testicular cancer has spread to nearby lymph nodes. The goal is to see if this method is accurate enough (at least 90% sensitive) to replace current staging approaches. About 44 adults with e…

This study tests whether a daily low-dose aspirin can prevent dangerous blood clots in people with advanced germ cell tumors (including testicular cancer) who are receiving standard chemotherapy. About 35 participants will take aspirin alongside their chemo for 26 weeks. The goal…

This early-stage study tests whether people with advanced solid tumors can safely follow a diet low in methionine, an amino acid found in many proteins. Researchers will measure how well participants stick to the diet, check for side effects, and track changes in blood methionine…

This study is creating a registry of people with germ cell or testicular tumors, along with their relatives and unrelated volunteers, to better understand why these tumors develop and how to improve prevention, diagnosis, and treatment. Researchers will collect medical history, f…

This study follows over 1,100 children and teens diagnosed with germ cell tumors to learn about short- and long-term side effects from treatment, especially hearing loss. Researchers will also analyze tumor DNA and other markers to better predict which patients might have a relap…

This study looks at 1650 people with different types of brain tumors to see if the new 2021 classification system helps doctors predict outcomes and choose treatments better than the old system. Researchers will collect information on treatments, scans, and survival over 5 years.…