FATIGUE

This study tests whether a specific exercise program called the GH Method can improve body composition, strength, and overall well-being in U.S. veterans who suffer from chronic pain, fatigue, or depression. About 25 veterans will do 90 exercise sessions over 18 months and comple…

This study looks at whether a simple strength training program can help breast cancer survivors manage fatigue. Researchers will work with 60 women from different backgrounds to see if factors like income and support affect how well they stick with the program. The goal is to fin…

This study tests whether a special nutrient supplement (APPORTAL®) can reduce cancer-related fatigue in breast cancer patients undergoing chemotherapy. About 92 women will receive either the supplement or a placebo for 8 weeks, alongside standard exercise advice. Researchers will…

This study tests whether an 8-week online Mindfulness-Based Stress Reduction (MBSR) program can reduce fatigue, anxiety, and depression in people with sarcoidosis. One group does MBSR with weekly sessions and daily journaling; the other joins a monthly virtual support group. Rese…

This study tests whether adding bright light therapy, methylphenidate, or melatonin to cognitive behavior therapy (CBT) can improve sleep, fatigue, anxiety, and depression in 188 adults with advanced cancer. Participants will receive CBT plus one of the add-on treatments or a pla…

This study is testing whether squeezing a stress ball during chemotherapy can help reduce nausea, anxiety, and fatigue in people with stomach cancer. About 52 adults will take part. Researchers will measure their symptoms during treatment to see if this simple, drug-free tool mak…

This study tests whether walking exercise can reduce fatigue in older breast cancer survivors. About 24 women aged 60 and older who completed cancer treatment will walk either at a center or at home for 12 weeks. The goal is to see which approach works better for easing tiredness…

This study looks at whether exercise therapy and cognitive behavioral therapy (CBT) can help reduce fatigue and improve treatment adherence in women with breast cancer. About 100 female patients in Singapore will take part. The goal is to see if these approaches are acceptable, c…

This study tests whether a special type of lighting that changes throughout the day can improve sleep, daily rhythms, and well-being in frail older adults (65+) staying in the hospital. Researchers will measure changes in melatonin levels and sleep patterns. The goal is to help p…

This study looks at whether a type of talking therapy (transdiagnostic cognitive behavioral therapy) can help people with long-term fatigue feel better. About 190 adults aged 18-67 with severe fatigue lasting at least 3 months will either get this therapy or usual care. The goal …

This study tests if a non-invasive brain stimulation technique called repetitive Transcranial Magnetic Stimulation (rTMS) can reduce fatigue in people with multiple sclerosis (MS). Sixty participants with MS and moderate-to-severe fatigue will receive either real or sham (fake) r…

This study tests whether a non-invasive magnetic brain stimulation technique called rTMS can reduce fatigue in people who had a stroke more than six months ago. About 60 participants will receive rTMS, and researchers will measure changes in fatigue, mood, and thinking. The goal …

This study tests whether a supplement from seaweed called fucoidan can help reduce fatigue and inflammation in people who have finished cancer treatment. About 40 cancer survivors with ongoing fatigue will take the supplement for 8 weeks. The goal is to see if it's practical to s…

This study tests whether aerobic exercise or cognitive behavioral therapy can reduce fatigue in people with myasthenia gravis (MG). About 60 adults with stable MG will be randomly assigned to one of three groups: exercise, therapy, or usual care. The goal is to see if these appro…

This study tests whether modafinil, a drug that promotes wakefulness, can reduce severe fatigue and thinking problems in people with advanced cancer. About 40 adults with stage III or IV cancer will receive either modafinil or a placebo for a short time. The goal is to see if the…

This study tests whether combining counseling and education with a placebo pill can better ease severe fatigue in people with advanced cancer, compared to either approach alone. About 240 adults with metastatic cancer and fatigue lasting at least 2 weeks will participate. The goa…

This study looks at how cancer survivors talk about fatigue, a common and often misunderstood side effect. Researchers will interview 80 survivors and their doctors to find common themes and words used. The goal is to create a simple visual poster that helps patients and doctors …

This study enrolls 257 adults with physical disabilities that limit mobility. Over 32 weeks, participants get access to exercise videos and wellness articles. Some also receive health coaching calls, and those who need extra support may get live group or one-on-one training. The …

This study aims to understand how the brain decides how much effort to put into tasks, both mental and physical. Researchers will measure how fatigue and rewards change our perception of effort. 185 healthy adults aged 18-35 will complete tasks and undergo brain scans to map the …

This study aims to understand what causes fatigue in people with Sjögren's disease. About 100 adults will complete surveys and pain tests at the start and again after 3 months. No new treatments are given—the goal is to gather information to help future care.