EPENDYMOMA

This study tests a combination of two drugs, cobolimab and dostarlimab, in children and young adults (up to age 21) with advanced solid tumors that have not responded to other treatments. The goal is to find the safest dose and see if the drugs can shrink tumors. The study involv…

This early-stage trial tests a new approach for children whose high-grade glioma has come back after standard treatments. It combines specially grown stem cells with an immunotherapy drug called nivolumab. The main goals are to see if the treatment is safe and possible to deliver…

This study looks at whether a wearable device called Optune is safe and practical for children with aggressive brain tumors. In one group, kids with recurrent high-grade glioma or ependymoma use the device alone. In another group, children with newly diagnosed DIPG use the device…

This early-phase study tests a modified virus designed to attack brain tumor cells that have come back or grown despite previous treatment. About 62 adults with certain types of brain cancer will receive the virus directly into the tumor, sometimes with a drug to boost the immune…

This early-phase study tests whether specially engineered immune cells (CAR T cells) can safely target and destroy brain tumor cells that have spread to the lining of the brain and spinal cord. Ten adults with glioblastoma, ependymoma, or medulloblastoma will receive these cells.…

This study tests whether adding the drug indoximod to standard chemotherapy and radiation can help children aged 3 to 21 with certain brain cancers. The drug aims to boost the body's immune system to fight tumors more effectively. The trial includes children with progressive glio…

This early-stage study tests a treatment made from a child's own immune cells, modified to recognize and attack a protein called HER2 found on ependymoma tumors. The goal is to see if it is safe and feasible for children whose tumor has returned or not responded to standard thera…

This early-phase study tests a cancer vaccine called SurVaxM in 35 children with brain tumors that have come back or are hard to treat. The vaccine is designed to teach the body's immune system to find and destroy tumor cells carrying a protein called survivin. The goal is to see…

This study tests whether surgery followed by a second course of radiation can help children and young adults (ages 1-21) whose ependymoma brain tumor has returned after initial treatment. The combined radiation dose is higher than usual, and researchers will closely monitor side …

This early-stage study tests whether specially engineered immune cells (CAR T cells) can be safely given directly into the brain or spinal fluid of children and young adults with HER2-positive brain tumors that have come back or not responded to standard treatments. The cells are…

This study looks at whether a special PET scan using a natural substance called methionine can help doctors see tumors in children and young adults with cancer. About 500 participants will get the scan to check if it can find tumors, tell how aggressive they are, and tell leftove…