EPENDYMOMA

This trial is testing a wearable medical device called Optune for children with aggressive brain tumors. The device uses low-intensity electric fields to try to slow or stop tumor growth. The study has two parts: one for kids whose tumors have come back, and another for kids newl…

This early-stage study is testing the safety of a new cell therapy for adults with aggressive brain cancers that have spread to the lining of the brain and spinal cord. Doctors take a patient's own immune cells, genetically modify them in a lab to recognize and attack cancer cell…

This early-stage trial is testing whether a combination of specially prepared stem cells and an immunotherapy drug (nivolumab) can help children and young adults with aggressive brain tumors that have returned after standard treatment. The study involves 12 participants aged 4-26…

This study is testing two repurposed cancer drugs, brigatinib and neratinib, to see if they can slow or stop the growth of tumors in people with NF2-related schwannomatosis. It will enroll about 100 participants aged 12 and older who have specific, growing tumors. The trial uses …

This early-stage study is testing a new treatment for children and young adults whose brain or spinal cord tumors have come back or haven't responded to standard therapies. Doctors collect the patient's own immune cells, modify them in a lab to recognize and attack cancer cells, …

This study is testing a new combination of two drugs, cobolimab and dostarlimab, for children and young adults with advanced solid tumors that have not responded to other treatments. The main goals are to find the safest and most effective dose and to see how well the body tolera…

This study is testing a cancer vaccine called SurVaxM in children and young adults with aggressive brain tumors that have come back or progressed. The vaccine is designed to teach the body's immune system to find and destroy cancer cells that carry a specific protein called survi…

This study is testing whether surgery followed by a carefully planned second course of radiation can help control ependymoma, a type of brain tumor, that has come back after initial treatment. It involves children and young adults (ages 1-21) whose tumor has progressed. The main …

This large study aimed to find out if adding chemotherapy after surgery and targeted radiation works better than surgery and radiation alone for children and young adults (ages 1-21) newly diagnosed with a brain tumor called ependymoma. It tested whether this extra 'maintenance' …

This early-stage trial is testing a new personalized treatment for children with ependymoma, a type of brain tumor that has come back or stopped responding to standard care. Doctors take a child's own immune cells, modify them in a lab to recognize and attack the tumor, and then …

This is a first-in-human safety study testing a genetically engineered virus, rQNestin34.5v.2, as a potential treatment for recurrent malignant brain tumors (gliomas). The virus is designed to infect and kill only cancer cells while sparing healthy brain tissue. The main goals ar…

This study is testing whether adding an immunotherapy drug called indoximod to standard chemotherapy and radiation can better control aggressive brain tumors in children and young adults. It is for patients aged 3 to 21 with certain progressive brain cancers or a newly diagnosed,…

This study is testing a new type of imaging scan to see if it can better detect and monitor tumors in children and young adults with cancer. The scan uses a radioactive form of a natural protein building block called methionine. Researchers want to see how well this new scan work…