DRY EYE

This study aims to create an artificial intelligence system that can automatically analyze confocal microscopy images of the cornea to diagnose dry eye disease. Researchers will collect eye scans from 75 adults (healthy and with dry eye) to train and test the AI. The goal is to r…

This study tests a small device that attaches to a smartphone to help diagnose dry eye disease. It takes special pictures of the eye's surface using different lights. The goal is to see if people can use it at home to get accurate results, compared to a standard eye exam. About 5…

This study will test a new, non-invasive eye scanner called wide field OCTA in 200 people with various eye diseases, including age-related macular degeneration, diabetic retinopathy, and dry eye. The goal is to see if this device can provide better images of blood vessels in the …

This study compares a new eye drop (perfluorohexyloctane) with a standard one (sodium hyaluronate) for people whose eyes get dry from using screens for more than 6 hours a day. Participants aged 18 to 70 with mild to moderate dry eye will use the drops four times daily for 8 week…

This study tests whether acoltremon eye drops can improve symptoms and tear production in people with dry eye disease over 12 months. Sixty adults will be randomly assigned to receive either the active drug or a standard artificial tear. Researchers will track changes in eye disc…

This Phase 3 trial tests whether CAM-101 eye drops can reduce eye discomfort and corneal damage in people with moderate to severe dry eye. About 475 adults will receive either CAM-101 or a placebo for 9 weeks, then all participants can switch to CAM-101 for a year. The study aims…

This study tests an experimental eye drop called RCI001 in 200 adults with dry eye disease. Participants will use the drops or a placebo for 4 weeks. The goal is to see if RCI001 reduces eye discomfort and damage to the eye's surface better than placebo. The study is not yet recr…

This small study tests whether a special VR headset, called Lacrima VR, can improve dry eye symptoms in people with dry eye disease and meibomian gland dysfunction. Twenty adults will either get the active treatment (light pulses through the headset) or a sham version with dimmer…

This study will observe 300 adults who have cataract surgery to see which of three tear substitute eye drops works best for reducing dry eye and discomfort. The drops contain different combinations of sodium hyaluronate, dexpanthenol, trehalose, and amino acids. Researchers will …

This study tests lifitegrast eye drops (Xiidra) in 30 adults with dry eye disease. Researchers will use a special microscope to see if the drops reduce immune cells on the eye surface. The goal is to ease dry eye symptoms and understand how the treatment works.

This study tests if adding sodium hyaluronate (a common moisturizer in artificial tears) to autologous serum eye drops provides better relief for moderate-to-severe dry eye disease. About 20 adults with dry eye from conditions like Sjögren's syndrome will use the new mix in one e…

This early-stage study tests whether a new eye ointment called RC017 is safe and tolerable in 24 healthy adults aged 18 to 55. The ointment is being developed to treat dry eye disease. Participants will receive either the ointment or a placebo, and researchers will monitor for si…

This study tests whether switching from Restasis to a new eye drop called acoltremon 0.003% can better relieve dry eye symptoms and improve tear production. About 100 adults with chronic dry eye who are dissatisfied with Restasis will take part. Researchers will measure changes i…

This study looks at whether switching from the dry eye drop Xiidra to a new drop called TRYPTYR (acoltremon 0.003%) can improve symptoms and tear production. About 100 adults with chronic dry eye who are already using Xiidra will take part. Researchers will measure tear productio…

This study aims to understand why some patients with severe dry eye syndrome improve with autologous serum eye drops while others do not. Researchers will analyze the protein makeup of the drops from 68 participants over 6 months. The goal is to identify which proteins are linked…

This study looks at how blinking behavior is linked to the stability of the tear film in adults aged 18 to 65, both with and without dry eye symptoms. Participants will answer a questionnaire, have their vision checked, and undergo non-invasive tear film measurements using an ima…

This study follows up with 220 people who previously took part in the Sjögren's International Clinical Collaborative Alliance (SICCA) study at the University of Pennsylvania. Researchers will collect tears, saliva, blood, and other samples, along with eye and mouth exams, to trac…