CORONARY HEART DISEASE

This study tests whether mazdutide, a weekly injection that helps with weight loss, can slow the buildup of fatty plaque in the heart arteries of 116 overweight or obese adults with coronary heart disease. Participants will receive either the drug or a placebo for 52 weeks, and d…

This study tests whether a medicine given as a nose spray before a heart stent procedure can reduce heart muscle injury or heart attack. About 1800 adults scheduled for elective stent placement will receive either the medicine or a placebo spray. Researchers will measure heart da…

This study tests whether a smartphone app can help people with coronary heart disease better manage their blood pressure and cholesterol after having a stent placed. About 792 participants will either use the app for one year or receive usual care. The app reminds patients to che…

This study looks at whether giving patients and their doctors a polygenic risk score — a genetic test that estimates future risk of coronary heart disease — helps more people start taking statins to prevent heart problems. Researchers will enroll 200 adults aged 40-69 without pri…

This observational study will follow 2,352 adults with coronary heart disease to see how factors like blood sugar, sleep, and heart imaging relate to thinking and memory problems. Participants will take memory tests and undergo scans and blood work during a hospital stay. The goa…

This study looks at 212 heart disease patients who take antiplatelet drugs and have sudden upper stomach bleeding. It compares having an endoscopy within 12 hours versus waiting 12-24 hours to see which timing is safer and more effective. The goal is to find the best approach to …

This study tests whether giving people with heart or lung conditions real-time air pollution data helps them exercise outdoors more safely. 80 participants will use a smartphone platform that tracks their walking and local air quality. The goal is to see if this approach reduces …

This large registry study will follow over 2,700 postmenopausal women aged 45-75 who use newer forms of hormone replacement therapy (creams, gels, sprays). The goal is to see if these modern delivery methods lower the risk of heart attacks, strokes, and other cardiovascular event…

This study will check if new risk models can better predict blood clots and bleeding in 5000 adults with coronary heart disease. Participants will be followed for one year to see how well the models work. The goal is to help doctors choose safer, more personalized treatments.

This study tests whether nutrition education provided by nurses can improve the eating habits and overall health of people who have recently had coronary artery bypass surgery. Researchers will enroll 160 patients and track their diet quality, weight, and well-being over time. Th…