COLON ADENOCARCINOMA

This phase 3 trial is testing whether adding the targeted drugs calderasib and cetuximab to standard chemotherapy can help people with a specific gene mutation (KRAS G12C) in advanced colorectal cancer live longer without their cancer growing. About 477 participants will receive …

This study looks at whether keyhole surgery (laparoscopic) or traditional open surgery leads to better long-term results for colon cancer patients who have extra belly fat. About 664 adults aged 18 to 75 with colon cancer and a high Body Roundness Index will take part. The main g…

This study tests whether adding the immunotherapy drug dostarlimab to standard chemotherapy (CAPEOX) before surgery works better than chemotherapy alone for a common type of colon cancer (MMRp/MSS). About 120 people with stage III or T4N0 colon cancer that has not been treated ye…

This study is for people with colon cancer who still have signs of cancer in their blood (ctDNA positive) after surgery and standard chemotherapy. It tests whether switching to a combination of two drugs (trifluridine/tipiracil and irinotecan) can clear those remaining cancer cel…

This study tests whether adding tolecizumab (a PCSK9 inhibitor) to standard chemoimmunotherapy can better shrink locally advanced colon cancer before surgery. About 106 adults with a specific type of colon cancer will receive either the combination or standard treatment alone. Th…

This study is testing whether giving a short course of immunotherapy drugs before surgery can improve outcomes for people with early-stage colon cancer. Participants will receive a combination of nivolumab, ipilimumab, and possibly other drugs for about 6 to 12 weeks before their…

This study tests a new treatment called CHM-2101 for people with advanced gastrointestinal cancers (stomach, colon, rectal, or neuroendocrine tumors) that have stopped responding to standard therapies. The treatment uses the patient's own immune cells, which are modified in a lab…

This phase 3 trial tests the immunotherapy drug dostarlimab against standard chemotherapy in 892 people with a specific type of colon cancer (dMMR/MSI-H) that has not spread. The goal is to see if dostarlimab alone can prevent cancer from coming back or causing death. Participant…

This study tests a new drug called QL1706 given before surgery for people with a specific type of colon cancer (MSI-H/dMMR) that has not spread far. About 363 participants will receive either QL1706 or standard care. The goal is to see if QL1706 can eliminate more tumor tissue be…

This study tests a less invasive surgery for people with early-stage colon cancer (stage I). Instead of removing a large section of the colon, doctors will remove only the tumor and a few nearby lymph nodes using a special dye. The goal is to see if this smaller surgery works as …

This study tests whether a liver transplant from a living donor can help people with colon cancer that has spread only to the liver and cannot be removed by surgery. About 25 adults will receive a partial liver from a healthy donor. The goal is to see if this approach helps them …

This study tests if wearing surgical gloves during oxaliplatin chemotherapy can prevent nerve damage in the hands. About 84 adults with advanced colon cancer will be randomly assigned to wear gloves or not during treatment. The goal is to see if this simple, low-cost method reduc…

This study looks at whether having a healthcare provider directly contact close relatives of people with newly diagnosed colorectal cancer leads to more genetic testing than having the patient share the information themselves. About 4,186 patients and their relatives will take pa…