COLON ADENOCARCINOMA
Clinical trials for COLON ADENOCARCINOMA explained in plain language.
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New vaccine aims to stop colorectal cancer recurrence in High-Risk patients
Disease control OngoingThis study tests an experimental vaccine (RO7198457) in people with stage II or III colorectal cancer who have signs of remaining cancer DNA in their blood after surgery. The goal is to see if the vaccine can prevent the cancer from returning better than simply watching and waiti…
Matched conditions: COLON ADENOCARCINOMA
Phase: PHASE2 • Sponsor: BioNTech SE • Aim: Disease control
Last updated Jul 02, 2026 04:00 UTC
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Immunotherapy combo aims to prevent colon cancer return in High-Risk patients
Disease control OngoingThis phase 3 trial is testing whether adding the immunotherapy drug atezolizumab to standard chemotherapy can help prevent cancer from coming back in people with stage III colon cancer that has a specific DNA repair defect (dMMR). About 712 participants will receive either chemo …
Matched conditions: COLON ADENOCARCINOMA
Phase: PHASE3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jul 02, 2026 04:00 UTC
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Can adding avastin to chemo stop stage II colon cancer from coming back?
Disease control OngoingThis phase III trial studies whether adding the drug bevacizumab (Avastin) to standard chemotherapy after surgery helps prevent cancer from returning in people with high-risk stage II colon cancer. Over 2,400 participants were randomly assigned to receive either chemotherapy alon…
Matched conditions: COLON ADENOCARCINOMA
Phase: PHASE3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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Could a drug replace surgery for some colon cancers?
Disease control OngoingThis phase II trial is testing whether the drug cemiplimab can control a specific type of colon cancer (dMMR) without needing surgery. About 50 adults with this cancer type will receive the drug through an IV. The main goal is to see if it is safe and effective enough to avoid an…
Matched conditions: COLON ADENOCARCINOMA
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:30 UTC
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New combo shows promise for Hard-to-Treat colorectal cancer
Disease control OngoingThis phase 2 trial is testing a combination of two drugs, cabozantinib and nivolumab, in 48 people with advanced colorectal cancer that has not responded to standard treatments. The goal is to see if the combination can shrink or stabilize tumors. All participants have a type of …
Matched conditions: COLON ADENOCARCINOMA
Phase: PHASE2 • Sponsor: University of Colorado, Denver • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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New drug cocktail aims to stop BRAF colon cancer in its tracks
Disease control OngoingThis study tests whether adding two targeted drugs (encorafenib and cetuximab) after standard surgery and chemotherapy can lower the chance of cancer coming back in people with a specific genetic type of stage II/III colon cancer (BRAF V600E). Participants either receive the drug…
Matched conditions: COLON ADENOCARCINOMA
Phase: PHASE2, PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated Jun 27, 2026 08:14 UTC
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New study seeks genetic clues to rising colorectal cancer in young adults
Knowledge-focused OngoingThis study investigates genetic factors that may increase the risk of developing colorectal cancer at a young age (18-50). Researchers will collect blood or saliva samples and review medical records from 818 participants, including patients and their family members. The goal is t…
Matched conditions: COLON ADENOCARCINOMA
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC