CHORDOMA

This study tests a stem cell transplant that removes certain immune cells (alpha/beta T cells and CD19+ B cells) and adds a drug called zoledronic acid. The goal is to help the donor cells attack the tumor without causing severe side effects. It is for children and young adults a…

This study offers expanded access to an experimental treatment called DNG64-CAR-V for people with advanced pancreatic cancer, sarcoma, or breast cancer. Up to 40 patients will receive the therapy intravenously or directly into tumors, alone or with other approved cancer drugs. Th…

This study compares carbon ion therapy, surgery, and proton therapy for people with pelvic bone sarcomas (a type of cancer). The goal is to see which treatment provides better disease control and fewer side effects, and to measure quality of life after treatment. About 72 partici…

This study compares two standard treatments—surgery and radiation therapy—for people with a rare spinal tumor called sacral chordoma that hasn't spread. About 100 adults will be assigned to one of the two treatments to see which better prevents the tumor from coming back or sprea…

This study is testing a shorter, more intense schedule of proton beam radiation therapy for people with rare, slow-growing tumors at the base of the skull called chordomas and chondrosarcomas. The goal is to see if giving the total radiation dose in just 5 sessions (or 27 for som…

This study follows people aged 2 and older with chordoma, a rare bone cancer, to understand how the disease changes over time. Researchers will collect medical history, imaging scans, and surveys about well-being and thinking skills. The goal is to gather information that can hel…