CHORDOMA

This study is testing whether three drugs given together can treat rare and aggressive childhood cancers caused by missing specific proteins. It will first find the safest dose and then see if the combination effectively controls these difficult tumors. The trial is for children …

This study is testing a new drug called ERAS-601 in people with advanced chordoma, a rare type of bone cancer that has continued to grow despite previous treatments. Researchers want to find out if ERAS-601 is safe and if it can help control the cancer by shrinking tumors or stop…

This study aims to determine whether surgery or radiation therapy works better for controlling primary sacral chordoma, a rare type of bone tumor near the tailbone. The trial will enroll 100 adults with newly diagnosed tumors who haven't had previous treatment. Participants will …

This program provides access to an experimental treatment called DNG64-CAR-V for patients with advanced pancreatic cancer, sarcoma, or breast cancer who have no other effective options left. The treatment uses a specially engineered virus designed to target and kill cancer cells …

This study is testing a new type of stem cell transplant for children and young adults whose solid tumors have returned or not responded to standard treatments. Doctors are using a donor's stem cells that have been specially processed to remove certain immune cells, then combinin…

This trial is testing a shorter, more convenient proton therapy schedule for people with rare, slow-growing tumors at the base of the skull called chordomas and chondrosarcomas. Instead of the standard treatment lasting many weeks, this approach delivers the radiation in just 5 s…

This study compares three different approaches for treating pelvic bone cancers (sarcomas) to see which one works best. Researchers are testing carbon ion radiation therapy against traditional surgery and proton radiation therapy. They want to find out which treatment gives patie…

This study aims to better understand chordoma, a rare bone cancer, by tracking people who have it over many years. Researchers will monitor how the disease progresses, how it responds to treatments, and how it affects people's daily lives. The information gathered will help desig…