CARDIOPULMONARY BYPASS

This study compares two ways of deciding when heart surgery patients need a blood transfusion in the ICU. One uses a fixed blood count threshold, while the other also considers each patient's oxygen and lactate levels. The goal is to see if the personalized approach is as safe an…

This study tests a drug called Angiotensin II for patients who develop dangerously low blood pressure after heart bypass surgery. About 329 adults will receive the drug along with standard treatments, and their outcomes will be compared to similar patients from the past. The goal…

This study tests whether the drug vericiguat can prevent serious heart and organ problems in people undergoing heart surgery. About 600 high-risk patients will receive either vericiguat plus standard care or standard care alone. The goal is to see if vericiguat reduces early comp…

This study compares two drugs, milrinone and epinephrine, to treat right heart dysfunction that can occur after cardiac surgery. The trial will enroll 102 adults undergoing heart surgery with a heart-lung machine. The goal is to see which drug better improves right heart function…

This study tests whether a drug called recombinant human brain natriuretic peptide (rhBNP), given continuously during and after heart surgery, can prevent acute kidney injury. It includes 694 high-risk adults undergoing elective heart surgery with a heart-lung machine. Participan…

This study tests whether injecting a local anesthetic near the stellate ganglion in the neck, guided by ultrasound, can improve how patients feel after heart surgery. The block temporarily calms part of the nervous system, which may reduce pain, improve sleep, and lower the risk …

This study compares two sedatives, remimazolam and midazolam, to see which one causes less confusion (delirium) after heart valve surgery in people aged 65 and older. Delirium affects up to 70% of older heart surgery patients and can lead to longer hospital stays and memory probl…

This study will look at data from 918 adults who had planned heart surgery to find out why some develop atrial fibrillation, a common and serious irregular heartbeat. The researchers will also examine whether newer anesthesia methods, like a nerve block, might help protect agains…

This study looks at whether placing patients face-down (prone) soon after heart surgery can improve how well the right side of the heart works. The idea is that this position helps open up collapsed parts of the lungs, making it easier for the heart to pump blood. About 80 adults…

This study will examine how the heart-lung machine used during cardiac surgery changes platelet function and metabolism. Researchers will take blood samples from 100 adult heart surgery patients at several time points. The goal is to link these platelet changes to post-surgery in…

This study looks at a device used during heart surgery to keep blood flowing. It will check for bleeding, damage, and leaks in 20 patients. The goal is to make sure the device is safe and works as intended.

This study looks at whether ventilating only one lung during heart-lung bypass surgery can reduce fluid buildup and lung damage in high-risk patients. Forty-five older adults having major elective heart surgery will take part. The goal is to see if this approach leads to better l…

This study looks at whether measuring antithrombin levels in the blood before heart surgery can predict if a patient will respond poorly to heparin, a blood thinner used during surgery. Researchers will collect one extra blood sample from 300 adults undergoing planned heart surge…

This study looks at whether a special breathing maneuver during heart surgery can improve heart and lung function in children with congenital heart disease. About 80 children will be randomly assigned to receive either the maneuver or standard care. The goal is to see if this app…