CARDIOPULMONARY BYPASS

This study tests a single dose of ravulizumab given before heart surgery to see if it can prevent kidney damage and serious kidney problems in people with chronic kidney disease. About 736 adults will take part. The goal is to reduce the risk of major kidney events within 90 days…

This trial investigates whether a single dose of amobarbital, an older sedative, can protect the heart muscle in adults undergoing cardiac surgery with a heart-lung machine. Researchers will measure how quickly the heart restarts after bypass and track recovery times and heart da…

This study tested a new way to monitor blood flow to the brain during heart surgery to prevent brain injury. It included 460 high-risk patients having heart surgery with a heart-lung machine. The goal was to see if this monitoring could reduce strokes, new brain lesions, or memor…

This study tested whether using low tidal volume (gentle) ventilation during heart-lung bypass surgery can lower the risk of postoperative delirium—a state of confusion that can slow recovery. Researchers compared 130 patients who received either low tidal volume ventilation or n…

This study tested whether using ideal body weight (instead of total body weight) to calculate heparin doses during heart-lung bypass reduces excessive bleeding in obese patients. Sixty obese adults scheduled for heart surgery were randomly assigned to receive heparin based on eit…

This study tested whether dexmedetomidine, a sedative that preserves breathing better than other drugs, can protect the heart during cardiac bypass surgery. Researchers measured heart damage in 224 adults undergoing heart surgery with a heart-lung machine. The goal was to see if …

This study tested whether using a measure of oxygen in the blood (SvO2) to guide red blood cell transfusions during heart surgery could reduce how many patients receive transfusions. Over 600 adults undergoing on-pump cardiac surgery were randomly assigned to either standard rest…

This study tested a special heart-protection method given during heart surgery to see if it could reduce damage to the heart muscle. 210 adults having aortic valve surgery took part. Researchers measured a protein called troponin I in the blood for 72 hours after surgery to check…

This study tested whether giving a low-dose sedative called dexmedetomidine at night can prevent delirium (sudden confusion) in older adults after heart surgery. The trial involved 504 patients aged 60-89 who had heart surgery with a heart-lung machine. The drug was infused overn…

This study looked at 68 adults having planned heart surgery that required a heart-lung machine. Researchers compared two different oxygenators (artificial lungs) to see if one caused more damage to platelets, the blood cells that help stop bleeding. They used a special test calle…

This study looked at 80 adults having heart valve or aortic surgery to find out how long a special heart protection solution (Del Nido cardioplegia) keeps the heart safe during surgery. Researchers took blood samples at set times to see when heart injury began. The goal was to le…

This study tested two different solutions used to protect the heart during coronary artery bypass surgery. Forty adults having non-emergency bypass surgery took part. Researchers measured heart enzyme levels and other recovery signs in the first two days after surgery to see whic…

This study looked at whether ultrasound measurements of the optic nerve sheath (the lining around the eye nerve) can detect changes in brain pressure during open-heart surgery when patients are on a heart-lung machine. Researchers measured the optic nerve sheath diameter in 40 ad…

This study looked at 38 adults who had heart surgery to better understand the heart damage that can occur. Researchers used cardiac MRI scans and blood tests for troponin (a heart damage marker) to measure and compare the extent of injury. The goal was to improve knowledge of how…

This study measured how fast pulse waves travel from the heart to different arteries in 40 patients undergoing heart surgery with a heart-lung machine. The goal was to see if this speed can detect when blood pressure in central arteries differs from that in arm or leg arteries. R…