ARTHROPLASTY REPLACEMENT, KNEE

This study tested the DePuy LCS Complete mobile-bearing total knee system in 241 people needing knee replacement due to arthritis. The goal was to see how well the implant and surgical tools work during and after surgery. Researchers measured implant survival, knee function, and …

This study compared an experimental oral anticoagulant called Dimolegin to the standard injectable drug Clexane for preventing venous thromboembolism (VTE) in 215 adults undergoing hip or knee replacement surgery. The goal was to see if the pill is as effective and safe as the in…

This study tested whether giving lidocaine through an IV works as well as an ultrasound-guided nerve block for controlling pain after total knee replacement. 120 adults having knee surgery were randomly assigned to receive either IV lidocaine or a saline placebo (with the nerve b…

This study tested whether a short behavioral program called Acceptance and Commitment Therapy (ACT) could reduce pain and improve function in veterans at risk for persistent pain after knee replacement. 402 veterans were randomly assigned to ACT or an attention control group. Res…

This study looked at 60 adults who had knee replacement surgery to see which of two nerve block combinations worked better for pain. One group got a biceps femoris short head block plus an adductor canal block, and the other got an IPACK block plus an adductor canal block. Resear…

This study looked at whether showing patients pictures of their damaged cartilage and new knee joint after surgery helps them feel better and move better early on. About 80 adults with severe knee arthritis who had a knee replacement took part. The goal was to see if seeing the p…

This study tested whether ear acupoint therapy (a type of acupuncture on the ear) can help people recover faster after total knee replacement surgery. 116 patients aged 50-80 participated. The therapy aimed to reduce pain, swelling, anxiety, and improve knee movement and scar hea…

This study looked at 20 people with severe knee arthritis who needed a knee replacement. They were randomly given one of two types of implants: a rotating platform or a fixed one. Researchers used 3D walking analysis before and after surgery to see which implant led to better wal…

This completed Phase 2 trial studied how the drug tranexamic acid (TXA) is processed in the body during hip or knee replacement surgery. 21 adults received a standard dose of TXA, and researchers measured drug levels in the blood to build a model for optimal dosing. The goal is t…

This study looked at whether physical rehabilitation after hip or knee replacement surgery is better than no rehabilitation for helping people with daily activities like walking and getting in and out of a car. 169 adults who had hip or knee replacement due to osteoarthritis took…