ACUTE ISCHEMIC STROKE DUE TO LARGE VESSEL OCCLUSION
Clinical trials for ACUTE ISCHEMIC STROKE DUE TO LARGE VESSEL OCCLUSION explained in plain language.
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Balloon trick after clot removal may shield the brain
Disease control CompletedThis study tested whether a special balloon procedure, called direct ischemic post-conditioning, can reduce brain injury in people who just had a stroke from a large blocked artery. Sixty patients were randomly assigned to get either standard clot removal alone or clot removal pl…
Matched conditions: ACUTE ISCHEMIC STROKE DUE TO LARGE VESSEL OCCLUSION
Phase: PHASE2 • Sponsor: Tianjin Huanhu Hospital • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New device aims to pull clots from the brain in major strokes
Disease control CompletedThis completed study tested a new device called the Supernova stent retriever in 55 people with severe stroke caused by a large blood clot in the brain. The device is threaded through blood vessels to grab and remove the clot, restoring blood flow. Researchers measured how often …
Matched conditions: ACUTE ISCHEMIC STROKE DUE TO LARGE VESSEL OCCLUSION
Phase: NA • Sponsor: Gravity Medical Technology, INC • Aim: Disease control
Last updated Jun 27, 2026 12:36 UTC
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Stroke drug tirofiban may boost recovery after clot removal
Disease control CompletedThis study tested whether giving the blood-thinning drug tirofiban after mechanical clot removal improves outcomes for people with severe stroke. Over 1,300 participants were randomly assigned to receive tirofiban or a placebo. The goal was to see if more patients could live inde…
Matched conditions: ACUTE ISCHEMIC STROKE DUE TO LARGE VESSEL OCCLUSION
Phase: PHASE2, PHASE3 • Sponsor: Xiang Luo • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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New device aims to clear stroke clots faster and safer
Disease control CompletedThis study tested a new device called the Millipede System in 246 stroke patients with large blood clots in the brain. The device is designed to remove clots and restore blood flow. Researchers measured how often blood flow was successfully restored and tracked any side effects. …
Matched conditions: ACUTE ISCHEMIC STROKE DUE TO LARGE VESSEL OCCLUSION
Phase: NA • Sponsor: Perfuze • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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Stroke breakthrough? drug may clear residual clots after standard treatment
Disease control CompletedThis phase 3 trial tested whether giving a clot-dissolving drug called tenecteplase directly into the brain artery can improve blood flow in stroke patients who still have blockages after standard mechanical clot removal. 156 adults with acute ischemic stroke were randomly assign…
Matched conditions: ACUTE ISCHEMIC STROKE DUE TO LARGE VESSEL OCCLUSION
Phase: PHASE3 • Sponsor: Insel Gruppe AG, University Hospital Bern • Aim: Disease control
Last updated Jun 27, 2026 09:03 UTC
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Experimental stroke drug RNS60 passes early safety check in small trial
Disease control CompletedThis Phase 2 trial tested the safety of an experimental drug called RNS60 in 83 people having a severe stroke caused by a large blood clot. Participants received either RNS60 or a placebo as a 48-hour infusion, starting within 30 minutes of consent. The main goal was to check for…
Matched conditions: ACUTE ISCHEMIC STROKE DUE TO LARGE VESSEL OCCLUSION
Phase: PHASE2 • Sponsor: Revalesio Corporation • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
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Could a bad mood or infection trigger a major stroke? scientists investigate
Knowledge-focused CompletedThis study aims to identify short-term triggers of acute ischemic stroke caused by large vessel occlusion, a severe type of stroke. Researchers will ask 302 patients about their exposure to potential triggers—such as infection, mood changes, smoking, alcohol, diarrhea, and extrem…
Matched conditions: ACUTE ISCHEMIC STROKE DUE TO LARGE VESSEL OCCLUSION
Sponsor: Anzhi Li • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:03 UTC
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Ear zaps after stroke: could a simple device tame brain inflammation?
Knowledge-focused CompletedThis study tested whether a mild electrical pulse on the ear (vagus nerve stimulation) can reduce inflammation after a stroke. Forty adults with a recent stroke received either standard care or standard care plus the ear stimulation. Researchers measured changes in blood markers …
Matched conditions: ACUTE ISCHEMIC STROKE DUE TO LARGE VESSEL OCCLUSION
Phase: NA • Sponsor: Washington University School of Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC