ACNE VULGARIS

This study compares two topical medications—clascoterone cream and adapalene gel—for treating mild acne vulgaris. Researchers will enroll 60 people aged 12 to 35 with mild acne and randomly assign them to use one of the treatments for 12 weeks. The goal is to see which treatment …

This study tests whether a low daily dose of the acne drug isotretinoin can clear moderate to severe acne as effectively as the standard dose, but with fewer side effects. About 164 people aged 18-45 will be randomly assigned to one of two dose groups. Researchers will track acne…

This study is testing a gel called CABTREO, which combines three acne-fighting ingredients (clindamycin, adapalene, and benzoyl peroxide), in children aged 9 to 11 with moderate to severe acne. The goal is to see if it is safe and works well over 12 weeks. About 100 kids will app…

This study tests three different gels for mild-to-moderate acne: a standard clindamycin-retinoid combo, a clindamycin-retinoid-dexamethasone combo, and a gel made from stem-cell secretions (secretome). About 189 people will use one of the three gels for 8 weeks. Researchers will …

This study tests a cream called clascoterone (1%) against a placebo in 692 people aged 12 and older with moderate to severe acne. Participants apply the cream to their face twice daily for 12 weeks. The goal is to see if the cream clears acne better than a placebo, with fewer sid…

This early-stage trial tests a new drug called HB0043, a bispecific antibody that targets two inflammatory proteins (IL-17A and IL-36R) linked to acne. About 21 adults with moderate to severe facial acne will receive either the drug or a placebo. The main goal is to check safety …

This study tests two prescription gels—metronidazole and clindamycin—to see which works better for moderate acne. Sixty adults aged 18 to 35 will apply the gel twice daily for 12 weeks. Doctors will check acne severity at the start and at weeks 4, 8, and 12 to measure improvement…

This study tests whether taking oral probiotics for 12 weeks can reduce acne lesions and lower inflammation in people with moderate acne. Researchers will compare probiotics to a placebo in 64 Pakistani participants aged 15-35. The goal is to find a safe, antibiotic-free way to m…

This study tests a new topical gel containing 5% spironolactone against a standard 0.1% adapalene gel for treating acne. Forty people with mild to moderate acne will apply each gel to opposite sides of their face, allowing direct comparison. The goal is to see if the spironolacto…

This study will test whether a gel containing dutasteride, a drug usually used for hair loss, can treat facial acne. Fifty adults with acne will apply the dutasteride gel to one side of their face and either a placebo or a standard triple-combination acne gel to the other side. R…

This study tests a new cream called KR230109 for mild to moderate acne. About 180 people aged 18 to 40 will use the cream or a placebo for 12 weeks. The goal is to see if the cream safely reduces pimples and skin bumps better than no treatment.

This study will measure three types of fats (ceramides and S1P) in the blood of 40 people with acne and 40 healthy volunteers. The goal is to see if these fats are different in acne patients and if they relate to acne severity. No treatment is given—just a blood draw. The results…