Ventricular septal defect 3
MONDO:0013749Any ventricular septal defect in which the cause of the disease is a mutation in the NKX2-5 gene.
Also known as: NKX2-5 ventricular septal defect (disease), ventricular septal defect (disease) caused by mutation in NKX2-5, ventricular septal defect 3, ventricular septal defect type 3, VSD3
66 clinical trials for this condition and its sub-types.
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Teaching teens with heart defects to take charge: a program aims to ease the leap to adult care
Disease control CompletedThis study tests whether a therapeutic education program helps teenagers and young adults with congenital heart disease transition from pediatric to adult medical care. Participants aged 13 to 25 will either receive the education program or standard follow-up. Researchers will me…
Phase: NA • Sponsor: University Hospital, Montpellier • Aim: Disease control
Last updated Jun 27, 2026 13:08 UTC
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Can a simple steroid help babies recover faster from heart surgery?
Disease control CompletedThis study tested whether giving the steroid methylprednisolone before and during heart surgery could reduce dangerous inflammation in infants under one year old. Over 1,200 babies were randomly assigned to receive either the steroid or a placebo (salt water). Researchers tracked…
Phase: PHASE3 • Sponsor: Kevin Hill • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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New heart valve implant offers hope for congenital heart patients
Disease control CompletedThis study tested a new valve called the Pulsta® Transcatheter Pulmonary Valve in 15 people with congenital heart disease and a faulty pulmonary valve. The valve is implanted through a catheter, avoiding open-heart surgery. Researchers checked if the valve improved blood flow and…
Phase: NA • Sponsor: Taewoong Medical Co., Ltd. • Aim: Disease control
Last updated Jun 26, 2026 13:31 UTC
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Can AI hear heart defects in children? a large trial puts it to the test
Diagnosis CompletedThis study is testing whether an artificial intelligence system can accurately identify congenital heart disease in children by analyzing heart sounds. It will involve thousands of children, with and without heart conditions, to compare the AI's performance against traditional me…
Sponsor: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine • Aim: Diagnosis
Last updated Aug 05, 2026 00:00 UTC
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New study aims to spot heart defects in newborns with simple blood test
Diagnosis CompletedThis completed study looked at 313 children to see if blood tests and advanced heart scans could help detect congenital heart disease earlier and predict which children might need surgery. Researchers compared children with heart defects to healthy controls using blood biomarkers…
Phase: NA • Sponsor: Lund University Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 12:30 UTC
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Cartoon or pamphlet? a trial tests which calms kids before a heart scan
Symptom relief CompletedThis trial compares two simple educational tools—an animated video and a brochure—against routine care to see which best lowers anxiety and fear in children aged 7 to 10 who need an echocardiogram. All participants have a congenital heart condition and are scheduled for a follow-…
Phase: NA • Sponsor: Merve Koyun • Aim: Symptom relief
Last updated Aug 01, 2026 00:00 UTC
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Ultrasound could make feeding tube placement safer for young heart patients
Symptom relief CompletedThis trial investigates whether using a bedside ultrasound machine can help doctors and nurses place feeding tubes more accurately in children aged 0 to 6 years who have congenital heart disease. The study will compare the accuracy of tube placement when ultrasound is used versus…
Phase: NA • Sponsor: Children's Hospital of Fudan University • Aim: Symptom relief
Last updated Jul 08, 2026 00:00 UTC
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Could virtual reality help kids heal after heart surgery?
Symptom relief CompletedThis study tested whether using virtual reality glasses during physical therapy can reduce pain, improve blood oxygen levels, and help children walk farther after open heart surgery. Forty children aged 6 to 12 took part. One group used VR glasses during their cardiac rehab exerc…
Phase: NA • Sponsor: Cairo University • Aim: Symptom relief
Last updated Jun 27, 2026 12:37 UTC
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Can interval training boost heart health in adults with congenital heart disease?
Symptom relief CompletedThis study looked at whether different types of exercise training can help adults with congenital heart disease exercise more easily. 47 participants were split into three groups: interval training, moderate continuous training, or usual care (no training). The main goal was to s…
Phase: NA • Sponsor: University of Alberta • Aim: Symptom relief
Last updated Jun 27, 2026 12:25 UTC
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New pain block helps kids recover from heart surgery with less opioids
Symptom relief CompletedThis study tested a special nerve block (serratus anterior plane block) to see if it could reduce pain and the need for strong painkillers like fentanyl in children after heart surgery. 48 children having heart surgery through a chest incision took part. The goal was to find a sa…
Phase: NA • Sponsor: Cairo University • Aim: Symptom relief
Last updated Jun 27, 2026 09:04 UTC
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Heart surgery in childhood: a hidden impact on speech and memory?
Knowledge-focused CompletedThis study looks at whether children born with heart defects who need surgery might also have delays in speech and thinking. Researchers will check the children's cognitive and language skills before their operation and again one and two years after. The goal is to see if speech …
Sponsor: Kemerovo State Medical University • Aim: Knowledge-focused
Last updated Aug 16, 2026 00:00 UTC
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Better blood tests could cut transfusions for young heart patients
Knowledge-focused CompletedThis study looked at new ways to test blood clotting in 200 children with congenital heart disease undergoing surgery. The goal was to see if newer technologies like TEG, ROTEM, and T2MR could help doctors manage bleeding more precisely and reduce the need for blood transfusions.…
Sponsor: Boston Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Heart ablation shows promise for congenital heart patients
Knowledge-focused CompletedThis study looked at how well a procedure called catheter ablation works for treating fast heart rhythms in people with congenital heart disease. Researchers treated 40 patients and followed them for one year to see if the abnormal heart rhythm came back. The goal was to understa…
Sponsor: Fayoum University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Heart surgery before 3 months: how do kids fare years later?
Knowledge-focused CompletedThis study looked at children aged 6 to 18 who had heart surgery before they were 3 months old. Researchers asked parents to fill out a questionnaire about their child's emotions, behavior, and social skills. The goal was to see if these children face any developmental challenges…
Sponsor: University Hospital, Toulouse • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:09 UTC
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Baby heart surgery study aims to protect tiny brains
Knowledge-focused CompletedThis study looked at 38 infants under 1 year old with congenital heart disease who needed heart surgery. The goal was to understand why some babies get brain injuries during surgery and to gather data for developing better monitoring tools. Researchers used MRI scans and blood sa…
Sponsor: University of Leicester • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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Heart surgery in childhood may leave kidneys at risk later
Knowledge-focused CompletedThis study measured how often teenagers develop chronic kidney disease after having heart surgery as young children. Researchers collected blood and urine samples from 120 teens aged 10 to 15 during their regular heart check-ups. The goal was to find out how common kidney damage …
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC
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Cheaper dialysis filters may work just as well in Kids' heart surgery
Knowledge-focused CompletedThis study looked at 60 children having heart surgery with a bypass machine. It compared two types of filters—hemofilters and hemodialyzers—to see which one better removes inflammatory substances called cytokines. The goal was to find out if the cheaper hemodialyzer could be a sa…
Phase: NA • Sponsor: Alnas Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:04 UTC
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Could a simple questionnaire unlock the secrets of Kids' eating disorders?
Knowledge-focused CompletedThis study tested a new parent questionnaire called ORALQUEST to assess feeding and eating disorders in children aged 9 months to 6 years. Researchers included 338 children with chronic conditions like heart defects or autism, as well as those with picky eating. The goal was to s…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:04 UTC