Varicocele
MONDO:0001498A condition characterized by the dilated tortuous veins of the spermatic cord with a marked left-sided predominance. Adverse effect on male fertility occurs when varicocele leads to an increased scrotal (and testicular) temperature and reduced testicular volume.
Also known as: scrotal varices, scrotum varicose disease, varicose disease of scrotum
19 clinical trials for this condition and its sub-types.
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Can fixing a varicocele beat antioxidants for boosting sperm?
Disease control CompletedThis trial tests whether microscopic surgery to repair varicoceles (enlarged veins in the scrotum) works better than antioxidant medication for men with cryptozoospermia—a condition where very few sperm are present in semen. About 69 men with clinical varicoceles will be randomly…
Phase: NA • Sponsor: Sohag University • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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Battle of the scalpels: which varicocele surgery is better?
Disease control CompletedThis study compared open surgery versus laparoscopic (keyhole) surgery for varicocele, a condition where veins around the testicle become enlarged. 100 men aged 20–60 were randomly assigned to one of the two procedures. Researchers measured how long the operation took, how many d…
Phase: NA • Sponsor: Lahore General Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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New varicocele surgery technique shows promise for male fertility
Disease control CompletedThis study tested two surgical methods to repair varicoceles (enlarged veins in the scrotum) in 60 men with fertility issues or pain. One group had a loupe-assisted surgery with a nitroglycerin spray to help see blood vessels, while the other had standard microscopic surgery. The…
Phase: NA • Sponsor: Fayoum University Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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AI matches doctors in spotting early vein disease
Diagnosis CompletedThis study tested whether an AI app (IVENUS) could correctly classify the severity of chronic vein disease from leg photos. Over 1,600 patients had their legs photographed, and the app's diagnosis was compared to that of experienced doctors. The goal was to see if the app could r…
Phase: NA • Sponsor: Clinic of Phlebology and Laser Surgery, Chelyabinsk, Russia • Aim: Diagnosis
Last updated Jun 27, 2026 09:10 UTC
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New inhaler may ease pain during male urology procedures
Symptom relief CompletedThis study tested whether breathing in a pain-relief medicine called Penthrox (methoxyflurane) can help reduce pain and anxiety during urologic procedures done with local anesthetic. Forty adult men having procedures like hydrocelectomy or testicular biopsy took part. The goal wa…
Phase: PHASE2 • Sponsor: University of Manitoba • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Gut protein zonulin: a hidden clue to male infertility?
Knowledge-focused CompletedThis study looks at whether levels of a protein called zonulin, found in blood and semen, differ between infertile men with and without varicocele (enlarged veins in the scrotum). Researchers will measure zonulin in 119 men and compare it with standard semen quality measures like…
Sponsor: Süleyman Tümer Çalışkan • Aim: Knowledge-focused
Last updated Aug 07, 2026 00:00 UTC
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Birth control pills under scrutiny for vein disease link
Knowledge-focused CompletedThis study looked at whether combined oral contraceptives (birth control pills) influence the development or worsening of chronic venous diseases, like varicose veins. Researchers followed 116 women taking different types of birth control pills. The goal was to see if these pills…
Phase: NA • Sponsor: Clinic of Phlebology and Laser Surgery, Chelyabinsk, Russia • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC