Urolithiasis

When a kidney stone blocks urine flow and causes a severe infection, doctors must quickly relieve the blockage and control the infection. They can place a stent through the urinary tract, insert a drainage tube through the skin, or start antibiotics alone. This study observes 1,6…

This study tests a new device that combines a camera and suction in one tool for kidney stone removal surgery. About 75 adults with kidney stones between 0.5 and 2.0 cm will undergo the procedure to see if the device safely clears stones and reduces leftover fragments. The goal i…

This trial tests whether a new flexible and navigable suction ureteral access sheath (FANS) works better than the standard sheath for removing kidney stones smaller than 2 cm in children. Sixty children will be randomly assigned to one of the two devices during a procedure called…

This trial tests whether a vacuum-assisted ureteral access sheath (ClearPetra) removes kidney stones more completely than a standard rigid sheath (Navigator) during flexible ureteroscopy. About 156 adults with stones 1-3 cm will be randomly assigned to one sheath. The main goal i…

This study compares a new tool called the CVAC system, used with a special scope, to standard treatments for removing kidney stones. About 1,000 adults who need stone removal will be randomly assigned to either the new method or usual care. The main goal is to see if the new appr…

This study compares a cheap medicine, sodium bicarbonate, to the standard prescription potassium citrate for preventing kidney stones. About 30 adults with a history of stones and low urinary citrate will take one of the two medicines. The goal is to see if sodium bicarbonate can…

This study tests whether a new system using cameras to track an ultrasound probe can help doctors find kidney stones faster in children undergoing shock wave lithotripsy. Eighty children with upper urinary tract stones will be randomly assigned to either the new camera-assisted m…

This study will compare two minimally invasive surgeries for kidney stones that are 2-3 cm in size. About 280 adults across nine hospitals will be randomly assigned to either FANS-based flexible ureteroscopy or suction-assisted mini-PCNL. The main goal is to see which method remo…

This study compares a new surgical tool called VISOR to a standard scope for removing kidney stones. VISOR combines suction, pressure control, and laser to break up and remove stones in one step. About 100 adults with stones up to 3 cm will be randomly assigned to get either VISO…

This study compares a new surgical technique, antegrade flexible ureteroscopy-assisted PCNL, to standard PCNL for removing large, branching kidney stones (staghorn calculi). The goal is to see if the new method removes more stone fragments and causes fewer complications. The tria…

This study tests whether rinsing the kidney with an antibiotic called dioxidine right after stone-removal surgery can stop infection-related stones from returning. About 95 adults with infection-type kidney stones will get either standard surgery alone or surgery plus the rinse. …

Researchers compare two minimally invasive operations for adults with bladder stones. One approach, transurethral cystolithotripsy, reaches the bladder through the urethra. The other, percutaneous cystolithotripsy, goes through a small puncture in the lower belly. The trial rando…

This study tests three common pain relievers (ibuprofen, paracetamol, and tenoxicam) against a placebo to see which works best during shock wave treatment for kidney stones. About 160 adults will rate their pain at several points during the procedure. The goal is to find the safe…

This study compares custom-length ureteral stents (based on each person's imaging) to standard one-size-fits-all stents in 128 adults having kidney stone surgery. The goal is to see if the custom stents reduce pain, urinary issues, and other symptoms. Participants will fill out a…

This study tests whether adding either dexamethasone (a steroid) or terbutaline (an asthma drug) to standard paracetamol provides better pain relief for people with kidney stones in the emergency room. About 300 adults with severe pain will be randomly assigned to one of the two …

This study compares a newer anesthesia drug, fospropofol disodium, with the standard drug propofol for people undergoing ureteroscopy (a procedure to remove kidney stones). About 190 adults will be randomly assigned to receive one of the two drugs during surgery. The main goal is…

This study compares three approaches to ureteral stenting after kidney stone surgery: no stent, a stent removed after 1 week, and a stent removed after 2 weeks. Researchers will track complications, patient comfort, and recovery in 90 adults with upper urinary tract stones. The g…

This study tests whether combining traditional Chinese five-element music therapy with herbal acupoint patches can reduce pain and anxiety in people undergoing kidney stone surgery under local anesthesia. Sixty adults with small kidney stones will be randomly assigned to receive …

This study compares lidocaine, a numbing drug, to morphine for treating severe kidney stone pain in the emergency room. Researchers will enroll 250 adults whose pain isn't relieved by standard treatment. The goal is to see if lidocaine provides better pain relief at 30 minutes, p…

This study looks at whether a retrolaminar block—a numbing injection near the spine—can reduce pain and improve comfort for people undergoing shock wave treatment for kidney stones. About 90 adults will be divided into three groups: one receiving the block, one receiving standard…

This pilot study tests a patient navigation program for people who visited the ER for kidney stones and are at risk of missing their follow-up urology appointment. About 31 participants will get a trained navigator who helps with scheduling, transportation, and other barriers for…

This study tests whether a scoring tool called a nomogram can accurately predict if a patient will be completely stone-free after a minimally invasive kidney stone surgery called flexible ureterorenoscopy. Researchers will compare the nomogram's predictions with actual surgical o…

This observational study investigates whether the ratio of the second to fourth finger length (2D:4D) is associated with urinary stone disease. Researchers will compare finger measurements between adults with kidney or ureteral stones and stone-free controls, all confirmed by CT …

This study will follow about 250 adults having a common kidney stone surgery called RIRS. Researchers will collect information before, during, and after surgery to find out which patients are more likely to develop fever or a serious infection called sepsis. The goal is to help d…