Ureteral disorder

This early-phase trial tests a combination of three drugs—enfortumab vedotin, pembrolizumab, and quemliclustat—in people with advanced bladder or urinary tract cancer that has spread or cannot be removed by surgery. The goal is to see if the combination is safe and effective. The…

This trial tests a new way to remove kidney stones using a special laser and a flexible suction sheath. 140 adults with stones between 6mm and 20mm will be randomly assigned to get the new suction sheath or a standard sheath. The goal is to see if the new method clears more stone…

This trial tests whether contrast-enhanced ultrasound (CEUS) using Lumason can detect kidney scarring as accurately as the standard DMSA scan, but without radiation. Children and young adults scheduled for a DMSA scan will receive an additional CEUS exam. If CEUS proves reliable,…

This study compares two imaging tests—PIC cystography and VCUG—for diagnosing vesicoureteral reflux (VUR) in children. VUR is a condition where urine flows backward from the bladder to the kidneys, which can lead to infections. The trial will enroll 60 children undergoing endosco…

This study tests three common pain relievers (ibuprofen, paracetamol, and tenoxicam) against a placebo to see which works best during shock wave treatment for kidney stones. About 160 adults will rate their pain at several points during the procedure. The goal is to find the safe…

This study tests whether combining traditional Chinese five-element music therapy with herbal acupoint patches can reduce pain and anxiety in people undergoing kidney stone surgery under local anesthesia. Sixty adults with small kidney stones will be randomly assigned to receive …

This study tests whether a scoring tool called a nomogram can accurately predict if a patient will be completely stone-free after a minimally invasive kidney stone surgery called flexible ureterorenoscopy. Researchers will compare the nomogram's predictions with actual surgical o…

This study looks at whether a special CT measurement, called the URSL Predictive Angle, can help doctors know ahead of time if a kidney stone surgery might need to switch to a different method during the procedure. Researchers will review records from 2,200 patients who had this …

This observational study will compare the gut and urine bacteria, as well as metabolic profiles, of 120 people with ureteral stricture (a narrowing of the tube from kidney to bladder) against healthy volunteers. Researchers aim to find differences that could explain why the condi…

This study will compare gut bacteria and blood markers between 270 kidney stone patients and healthy people in Shanghai. Researchers want to see if hot, humid weather changes gut microbes and tryptophan metabolism in ways that promote stone formation. No treatment is given; the g…