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Trigeminal neuralgia
MONDO:0008599Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. The pain lasts a few seconds to a few minutes, and usually on only one side of the face. It can also cause muscle spasms in the face the same time as the pain. The pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of theface), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor or cyst. In some cases, the cause is unknown. Treatment options include medicines, surgery, and complementary approaches.
Also known as: neuralgia of trigeminal nerve, trigeminal nerve neuralgia, trigeminal neuralgia, Tic douloureux
42 clinical trials for this condition and its sub-types.
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Laser test could objectively measure nerve pain for first time
Diagnosis CompletedThis study tested whether a diode laser can act as a biomarker to measure neuropathic pain in people with peripheral neuropathy. Researchers compared pain responses to a lidocaine patch versus a placebo patch in 75 participants. The goal was to see if the laser test could disting…
Phase: NA • Sponsor: University of Utah • Aim: Diagnosis
Last updated Jun 27, 2026 12:09 UTC
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Pain relief showdown: one drug vs. two for facial nerve pain
Symptom relief CompletedThis study tested whether taking gabapentin along with oxcarbazepine works better than oxcarbazepine alone for trigeminal neuralgia, a condition causing severe facial pain. 44 adults were split into two groups and had their pain measured over 2 months. The goal was to see which a…
Phase: PHASE2, PHASE3 • Sponsor: Rehman Medical Institute - RMI • Aim: Symptom relief
Last updated Jun 27, 2026 13:03 UTC
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New drug aims to ease severe facial pain in trigeminal neuralgia
Symptom relief CompletedThis study tested a new drug called SR750 in 138 people with trigeminal neuralgia, a condition that causes sudden, severe facial pain. Participants took either SR750 or a placebo for 6 weeks and recorded their daily pain levels. The goal was to see if SR750 reduces pain better th…
Phase: PHASE2 • Sponsor: Shanghai SIMR Biotechnology Co., Ltd. • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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New hope for migraine sufferers? Needle-Freezing technique targets pain hub
Symptom relief CompletedThis study tested a minimally invasive procedure called pulsed radiofrequency on a nerve bundle in the face (the sphenopalatine ganglion) to see if it could reduce pain in 55 people with chronic headaches or facial pain who hadn't gotten relief from medication. The procedure uses…
Phase: NA • Sponsor: Ankara City Hospital Bilkent • Aim: Symptom relief
Last updated Jun 27, 2026 11:02 UTC
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Migraine drug shows promise for rare facial nerve pain
Symptom relief CompletedThis study tested a drug that blocks a pain-signaling protein (CGRP) in 26 adults with trigeminal or glossopharyngeal nerve pain caused by small fiber neuropathy or fibromyalgia. The goal was to see if it reduces pain and the need for other pain medications, while checking for si…
Phase: PHASE4 • Sponsor: Duke University • Aim: Symptom relief
Last updated Jun 27, 2026 09:01 UTC
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New combo therapy may offer lasting pain control for facial nerve condition
Symptom relief CompletedThis study tested whether a combination of nucleotides and B vitamins (Nucleo CMP and Neurorubine) could provide better and longer-lasting pain relief than the standard drug carbamazepine for people with trigeminal neuralgia, a severe facial pain condition. 38 adults with classic…
Phase: PHASE2 • Sponsor: Karbala University • Aim: Symptom relief
Last updated Jun 27, 2026 08:06 UTC
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Teflon placement in brain surgery may affect pain return
Knowledge-focused CompletedThis study looked at 150 patients who had surgery for trigeminal neuralgia, a condition causing severe facial pain. Surgeons used a Teflon implant to cushion a blood vessel pressing on a nerve. The study compared two ways of placing the Teflon—either directly against the nerve or…
Sponsor: University of Valencia • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC