Trigeminal neuralgia
MONDO:0008599Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. The pain lasts a few seconds to a few minutes, and usually on only one side of the face. It can also cause muscle spasms in the face the same time as the pain. The pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of theface), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor or cyst. In some cases, the cause is unknown. Treatment options include medicines, surgery, and complementary approaches.
Also known as: neuralgia of trigeminal nerve, trigeminal nerve neuralgia, trigeminal neuralgia, Tic douloureux
42 clinical trials for this condition and its sub-types.
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AI boosts brain scan accuracy in massive new trial
Diagnosis ENROLLING_BY_INVITATIONThis study tests whether an AI tool can help radiologists read brain CT and MRI scans more accurately and quickly. Researchers will compare how well doctors, AI alone, and doctors using AI together can spot abnormalities, urgent findings, and classify diseases. The goal is to red…
Sponsor: Yaou Liu • Aim: Diagnosis
Last updated Jun 27, 2026 11:00 UTC
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Magnetic pulses to the brain may ease stubborn nerve pain
Symptom relief OngoingThis study tests whether repeated magnetic pulses (rTMS) aimed at the brain's motor area can safely reduce chronic nerve pain that hasn't responded to other treatments. About 32 adults with conditions like post-stroke pain, trigeminal neuralgia, or spinal cord injury will receive…
Phase: NA • Sponsor: University of California, San Francisco • Aim: Symptom relief
Last updated Jun 27, 2026 11:01 UTC
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Sound waves zapping pain: new hope for facial neuralgia?
Symptom relief OngoingThis early-phase study tests whether MRI-guided focused ultrasound can safely reduce severe facial pain in people with trigeminal neuralgia that hasn't responded to medication. Ten adults aged 21-75 with chronic pain for over 6 months will receive a precise ultrasound treatment t…
Phase: NA • Sponsor: University of Maryland, Baltimore • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
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New pill could ease the 'Suicide Disease' for patients failed by current meds
Symptom relief OngoingThis study tests a daily drug called basimglurant for adults with trigeminal neuralgia, a condition causing severe facial pain often called the 'suicide disease.' The trial includes 166 people who still have pain despite current treatments. After an 8-week run-in on the drug, par…
Phase: PHASE2, PHASE3 • Sponsor: Noema Pharma AG • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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Head-to-Head: which drug tames facial nerve pain better?
Symptom relief OngoingThis study compares carbamazepine and oxcarbazepine, two drugs used to treat trigeminal neuralgia, a condition causing severe facial pain. Researchers will enroll 122 adults aged 18-60 who have had the condition for at least two weeks. They will measure pain relief using a standa…
Phase: NA • Sponsor: Abbasi Shaheed Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 08:00 UTC
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Face mask zaps nerve pain: new hope for trigeminal neuralgia?
Symptom relief OngoingThis study tests a precise radiation treatment for trigeminal neuralgia, a condition that causes severe facial pain. Instead of a metal frame screwed into the skull, a special face mask holds the head still while x-rays target the painful nerve. The trial includes 40 adults whose…
Phase: NA • Sponsor: University of Alabama at Birmingham • Aim: Symptom relief
Last updated Jun 27, 2026 07:54 UTC
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AI and VR join forces to fight severe facial pain
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks at people with trigeminal neuralgia, a condition that causes severe facial pain. Researchers want to see if adding virtual reality (VR) training before Gamma Knife surgery can improve pain relief. They will also use artificial intelligence (AI) and brain scans to…
Phase: NA • Sponsor: IRCCS San Raffaele • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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Researchers probe hidden jaw pain in nerve disorder patients
Knowledge-focused TerminatedThis study aimed to find out how many people with trigeminal neuralgia (a severe facial nerve pain condition) also have temporomandibular disorder (TMD), which causes jaw pain. Researchers planned to follow patients from three clinics and test a questionnaire to better diagnose b…
Sponsor: University of Minnesota • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC