Substance dependence
MONDO:0004938The psychological or physiological need to take a substance in order to experience its effects or to avoid the effects of its absence.
Also known as: dependence
1374 clinical trials for this condition and its sub-types, 15 tagged with Substance dependence itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Substance dependence
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Drug dependence 14 trials · 1,285 incl. sub-types
10 sub-types
- Opiate dependence 545 trials Sub-types →
- Nicotine dependence 412 trials
- Cannabis dependence 218 trials
- Methamphetamine dependence 63 trials
- Cocaine dependence 52 trials
- Alcohol dependence 44 trials
- Hallucinogen dependence 1 trial
- Alcohol and nicotine codependence 0 trials
- Barbiturate dependence 0 trials
- Phencyclidine abuse 0 trials
Most studied deeper sub-types
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New peer support program aims to cut substance abuse and HIV risk in transgender community
Disease control Recruiting nowThis study tests a mutual-help group called the TLC Program for transgender adults who struggle with substance use or are recently in recovery. The program uses mindfulness and values-based skills from Acceptance and Commitment Therapy to improve mental health and reduce HIV risk…
Sponsor: Illinois Institute of Technology • Aim: Disease control
Last updated Jul 17, 2026 00:00 UTC
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New combo therapy aims to curb meth use in canadian trial
Disease control Recruiting nowThis study tests whether adding a high-dose stimulant medication and/or a reward-based program (contingency management) to standard care helps people reduce how often they use methamphetamine. About 440 adults with moderate to severe methamphetamine use disorder will be randomly …
Phase 2 • Sponsor: Centre hospitalier de l'Université de Montréal (CHUM) • Aim: Disease control
Last updated Jun 27, 2026 09:02 UTC
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Brain zaps to beat cravings: paris trial tests tDCS for smokers
Symptom relief Recruiting nowThis study tests whether a non-invasive brain stimulation technique called tDCS can reduce cravings in people addicted to nicotine. One hundred daily smokers who are highly dependent will receive tDCS sessions. The goal is to see if this painless, mild electrical stimulation can …
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Symptom relief
Last updated Jun 26, 2026 16:02 UTC
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Teen brain scans may predict cannabis treatment success
Knowledge-focused Recruiting nowThis study looks at whether brain activity related to learning can predict how well teens respond to a program aimed at reducing cannabis use. Teens aged 14-17 get a brain scan, then attend 10 weekly virtual sessions where they report use and take drug tests. They can earn prizes…
Sponsor: Indiana University • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:01 UTC
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Massive study tracks 10,000 people with addiction to uncover what really helps
Knowledge-focused Recruiting nowThis study is following 10,000 people who are seeking help for substance or behavioral addictions. Researchers will track their medical, brain, social, and psychological health over several years using interviews, questionnaires, and cognitive tests. The goal is to better underst…
Sponsor: Centre Hospitalier Charles Perrens, Bordeaux • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC