Spasmodic dystonia

This early-phase trial tested whether injecting a patient's own stem cells into scarred vocal folds could safely improve severe hoarseness. Nine adults with untreatable voice problems received the stem cell injection during surgery. Researchers monitored side effects and voice fu…

This study tested a small clip attached to the breathing tube used during anesthesia to see if it could prevent sore throat, voice changes, and trouble swallowing after surgery. 100 adults having surgery with general anesthesia took part. The clip is designed to reduce pressure o…

This study tested a small vibrating device worn on the neck to see if it could make speaking easier for people with spasmodic dysphonia, a rare voice disorder. Forty participants used the device at home for 20 minutes a day over 8 weeks. They reported how much effort it took to s…

This study tested a new type of botulinum toxin injection (DAXI) for people with adductor spasmodic dysphonia, a condition that causes the voice to spasm and sound strained. 22 adults who had previously been helped by standard Botox injections received a single DAXI injection int…

This study looked at whether giving a low dose of a muscle relaxant (rocuronium) during bronchoscopy—a procedure where a tube is inserted into the lungs—could reduce complications like throat spasms and coughing. 153 adults having elective bronchoscopy were split into two groups:…

This study looked at whether applying an ice compress to the neck before botulinum toxin injections can reduce pain for people with spasmodic dysphonia, a chronic voice disorder. 116 adults received either ice or no ice before their injection and then filled out a pain questionna…

This study compared two types of exercises for adults with long-term neck pain. After six weeks, those who did cervical stabilization exercises had greater improvements in pain, daily function, head posture, and voice efficiency than those who did traditional exercises. Both grou…

This study tested whether a single dose of sodium oxybate can improve voice symptoms in people with spasmodic dysphonia and voice tremor. 117 adults received the drug or a placebo, and researchers measured changes in symptom severity. The goal was to see if the drug could mimic t…

This study tested two non-drug treatments for paradoxical vocal fold motion (PVFM), a condition where vocal cords close when they should open, causing shortness of breath. Fifty-one adults were randomly assigned to either biofeedback (watching their breathing on a screen) or lary…

This study tested whether amifampridine can reduce temporary voice weakness and breathiness that often occurs in the first few weeks after Botox injections for spasmodic dysphonia (a voice disorder). 18 adults who regularly get Botox for this condition took part. The goal was to …

This completed study from the National Institute of Neurological Disorders and Stroke aimed to better understand how the brain controls movement and what goes wrong in movement disorders like Parkinson's disease, Tourette's syndrome, and dystonia. Over 1,200 adults—both patients …

This study looked at how using high-flow nasal oxygen during laryngeal surgery affects the heart and blood vessels. Twenty relatively healthy adults were monitored for changes in heart function compared to standard breathing support. The goal was to understand potential risks, no…

This study looked at 102 adults with dystonia, a condition causing involuntary muscle contractions. Researchers used questionnaires and brain wave recordings to assess memory, attention, mood, and decision-making. The goal was to better understand the non-motor symptoms of dyston…

This completed study tested two ways of helping patients breathe during microscopic throat surgery. One method uses a steady airflow, while the other uses a set volume of air. The goal was to see which method keeps airway pressure lower and safer. 68 adults having elective laser …

This study looked at how voice and swallowing change after a second neck spine surgery. Two hundred patients had their vocal cords and swallowing checked before and about three weeks after surgery. They also filled out a short quality-of-life survey. The goal was to better unders…

This study looked at whether giving patients online educational modules before starting voice therapy helps them stay engaged and attend more sessions. Researchers enrolled 42 adults with voice problems (dysphonia) who were recommended for voice therapy. The goal was to see if th…

This study tested a wrist-worn device called the Personal KinetiGraph (PKG) to see if it can accurately measure movement problems in people with Parkinson's disease. Nineteen participants wore the device while researchers compared its readings to standard clinical tests and video…