Sleep-wake disorder
MONDO:0003406Abnormal sleep-wake schedule or pattern associated with the circadian rhythm which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle. These can include dyssomnias such as circadian rhythm disorders, hypersomnia, and sleep apnea and parasomnias such as bruxism and rapid eye movement sleep disorder.
Also known as: disorder of sleep-wake cycle, sleep wake disorder, Subwakefullness syndrome, Subwakefullness syndromes, Tachypneas, sleep-related neurogenic, disorder of sleep-wake schedule, disorder, sleep, disorder, sleep wake
1063 clinical trials for this condition and its sub-types, 179 tagged with Sleep-wake disorder itself.
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Sub-types of Sleep-wake disorder
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Sleep apnea syndrome 214 trials · 603 incl. sub-types
2 sub-types
- Obstructive sleep apnea syndrome 519 trials · 520 incl. sub-types Sub-types →
- Central sleep apnea syndrome 21 trials · 23 incl. sub-types Sub-types →
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Circadian rhythm sleep disorder 103 trials · 138 incl. sub-types
8 sub-types
- Circadian rhythm sleep disorder, shift work type 35 trials
- Circadian rhythm sleep disorder, delayed sleep phase type 12 trials
- Rapid eye movement sleep disorder 4 trials
- Circadian rhythm sleep disorder, irregular sleep wake type 3 trials
- Circadian rhythm sleep disorder, jet lag type 2 trials
- Non-24-hour sleep-wake syndrome 2 trials
- Circadian rhythm sleep disorder, advanced sleep phase type 1 trial
- Advanced sleep phase syndrome 0 trials Sub-types →
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Narcolepsy 38 trials · 57 incl. sub-types
3 sub-types
- Narcolepsy-cataplexy syndrome 42 trials · 44 incl. sub-types Sub-types →
- Narcolepsy without cataplexy 22 trials
- Hereditary narcolepsy 0 trials · 5 incl. sub-types Sub-types →
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Bruxism 56 trials
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Hypersomnia 24 trials · 50 incl. sub-types
1 sub-type
- Idiopathic hypersomnia 28 trials Sub-types →
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REM sleep behavior disorder 48 trials
1 sub-type
- Rapid eye movement sleep disorder 4 trials
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Periodic limb movement disorder 2 trials
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Recurrent hypersomnia 0 trials
1 sub-type
- Kleine-Levin syndrome 0 trials
Most studied deeper sub-types
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Migraine drug ajovy put to the test for better sleep
Disease control Stopped earlyThis study looked at whether fremanezumab (Ajovy), an FDA-approved monthly injection for migraine prevention, could also improve sleep in people with migraines. Researchers planned to track 22 participants over 4 months, comparing their migraine days and sleep quality before and …
Phase 4 • Sponsor: Beth Israel Deaconess Medical Center • Aim: Disease control
Last updated Jun 27, 2026 09:09 UTC
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Can a restless legs drug ease opioid withdrawal?
Symptom relief Stopped earlyThis study tested whether pramipexole (Mirapex), a drug for restless legs syndrome, could also reduce symptoms of opioid withdrawal in people with opioid use disorder. The trial planned to enroll 75 adults but was terminated early. Researchers measured changes in restless legs se…
Phase 2/3 • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Sleep study for ICU sedation halted after just 3 volunteers
Knowledge-focused Stopped earlyThis study aimed to see if a sedative called dexmedetomidine produces sleep more like natural sleep than another sedative, propofol. Researchers planned to measure brain activity in 3 healthy volunteers during drug-induced and natural sleep. The trial was terminated early, so onl…
Phase 1 • Sponsor: University of California, San Francisco • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:02 UTC
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Sleep troubles linked to suicide attempts? study investigates
Knowledge-focused Stopped earlyThis study looked at whether sleep disorders like insomnia and nightmares are connected to suicide attempts. Researchers compared people who had just attempted suicide with those who had suicidal thoughts but no attempt. The goal was to see if sleep problems might be a trigger. T…
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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Mental health study aims to uncover Long-Term heart risks
Knowledge-focused Stopped earlyThis study followed 167 adults with mental health issues like anxiety, depression, or sleep problems who visited their primary care doctor. Researchers used health conversations and a blood test to track lifestyle changes and heart disease risks over up to 20 years. The goal was …
Sponsor: Region Skane • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:28 UTC