Salmonellosis

This study tests a new quadrivalent Pan-Salmonella vaccine designed to protect against several types of Salmonella bacteria that cause typhoid and paratyphoid fevers. Healthy adults aged 18 to 45 in Africa receive either a low or full dose of the vaccine, with or without an adjuv…

This study is testing a new vaccine called iNTS-TCV in 537 infants in Africa. The vaccine is designed to protect against two serious bacterial infections: invasive nontyphoidal salmonella (iNTS) and typhoid fever. Researchers are giving the vaccine to infants starting at either 6…

This study compares two antibiotics, azithromycin and meropenem, given through a vein to treat extensively drug-resistant enteric fever (a severe typhoid infection). Researchers will enroll 40 patients aged 1 to 70 years to see which drug clears the infection faster and reduces f…

This study looks at whether the R21/Matrix-M malaria vaccine can also reduce the risk of invasive non-typhoidal Salmonella (iNTS), a serious bacterial infection. Researchers will follow 10,000 children under 5 in the Democratic Republic of Congo who come to health centers with fe…

This study gives healthy adults the licensed oral typhoid vaccine (Vivotif) and collects blood, saliva, and stool samples over up to eight years. Researchers want to learn how the vaccine triggers protective immune responses, which could help design better vaccines for typhoid an…

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…