Rickets

This study looks at whether lowering high parathyroid hormone levels can help protect bone density in people with advanced chronic kidney disease. About 70 adults aged 50 and older with kidney failure not on dialysis will be assigned to different treatment targets for their hormo…

This study looks at three different ways to take vitamin D in people with low levels. Participants will be randomly assigned to one of three groups: a monthly pill, a twice-monthly pill, or daily drops. After one month, researchers will measure vitamin D in the blood and check bo…

This study tests a new drug called KK8123 for adults with X-linked hypophosphatemia (XLH), a rare genetic condition that causes low phosphate levels and bone problems. The trial has two parts: first, finding the right dose, then checking safety and how well it works over time. Ab…

This study uses a special MRI technique to measure energy molecules (ATP and phosphate) in the leg muscles of people with phosphate diabetes, a condition that causes bone pain and muscle fatigue. By comparing measurements at rest and during exercise, researchers hope to uncover t…

This study is a worldwide registry that collects health information from people of all ages with X-Linked Hypophosphatemia (XLH), a rare genetic condition that affects bone growth and strength. Researchers will track how the disease progresses, what treatments patients receive, a…

This study gives 200 athletes either high-dose vitamin D3 (4,000 IU daily) or a placebo for 4 to 8 weeks. Researchers measure changes in vitamin D levels, hormones, muscle function, cognitive performance, and body composition. The goal is to see if extra vitamin D improves athlet…

This study is testing whether a blood test that looks at tiny genetic molecules called microRNAs can accurately detect bone problems in people with chronic kidney disease. Currently, doctors rely on a bone biopsy, which is invasive and not practical for most patients. The researc…

This study looks at how long-term phosphate therapy affects the kidneys, blood vessels, and heart in people with two rare bone disorders: X-linked hypophosphatemia (XLH) and hereditary hypophosphatemic rickets with hypercalciuria (HHRH). Researchers will measure hormone levels an…

This study tests a new, non-invasive method using calcium isotope ratios in blood to see if the drug cinacalcet improves bone calcium balance in children aged 3-17 who are on dialysis and have secondary hyperparathyroidism. Researchers will measure these ratios before and three m…

XLH is a rare genetic condition that causes low phosphate levels, leading to weak bones and pain. Burosumab is a standard treatment, but the best starting dose is still unclear. This study will review the medical records of 120 children across England to see if a lower dose (unde…

This study looks at bone cells from children having surgery for craniosynostosis (early skull bone fusion). Researchers want to see how burosumab and vitamin D directly affect these cells, especially in children with a rare bone disease called hypophosphatemic rickets. The goal i…

This study will follow 1,000 adults who are taking vitamin D supplements for low vitamin D levels. Researchers will collect health data over 10 years to see how vitamin D use relates to conditions like heart disease, diabetes, cancer, and osteoporosis. The goal is to learn more a…

This study is testing how different levels of dietary phosphorus affect people with moderate chronic kidney disease (stages 3-4) compared to healthy volunteers. Participants will follow three different phosphorus diets over 21 days, and researchers will measure blood markers to f…

This study aims to understand the link between calcium and phosphorus from food and the stage of kidney disease in patients with advanced chronic kidney disease (stage 4-5). Researchers will compare two methods of tracking diet: taking photos of meals and weighing food. The goal …

This study looks at how taking vitamin D3 and K2 supplements for 90 days changes blood levels and the community of bacteria in the gut (the microbiome) in healthcare workers with low vitamin D. About 96 participants will take either a vitamin D3, K2, both, or a placebo pill. Rese…

This study is looking at 100 children aged 3 to 15 who have had a low-energy fracture (like a fall from standing height). Researchers want to see if vitamin D levels, bone markers, and weight are linked to fracture risk. They will compare children with fractures to those without.…