Respiratory distress syndrome in premature infants

This study tests whether giving surfactant (a natural substance that helps lungs stay open) through a small airway device placed above the vocal cords, along with standard breathing support (CPAP), is better than CPAP alone for late preterm and early term infants with respiratory…

This study is testing whether giving each patient on a ventilator a personalized oxygen target (based on their unique health data) leads to better outcomes than standard care. Researchers will compare death rates and time spent on the ventilator between the two groups. The trial …

This Phase 3 trial tests whether adding budesonide (an anti-inflammatory) to standard surfactant treatment helps extremely preterm babies avoid chronic lung disease or death. About 642 infants born before 29 weeks or weighing under 1000 grams will receive either the combo or surf…

This study tests whether robot-assisted leg exercises can prevent older patients from losing strength and independence during a hospital stay. 488 patients aged 65 and older will either receive robot-guided training or standard care. The goal is to see if the robot helps them wal…

This pilot study tests whether home-based or video-supervised exercise programs are acceptable and helpful for people with chronic lung diseases like IPF, sarcoidosis, bronchiectasis, asthma, and other interstitial lung diseases. Fifty participants will be randomly assigned to on…

This study looks for biological markers in blood and lung samples from people with idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases. The goal is to find markers that can predict how the disease will progress and to group patients into subtypes. Researchers…

This study looks at whether a simple bedside lung ultrasound can predict chronic lung disease in premature infants born before 32 weeks. Researchers will perform ultrasounds on 150 babies with breathing problems and track their outcomes. The goal is to see if early ultrasound sco…

This study observes how the diaphragm works in 100 adults with acute respiratory failure who need non-invasive breathing support or high-flow oxygen. Researchers use ultrasound to measure diaphragm movement and thickness at different support levels. The goal is to understand how …

This study looks at how things in the environment and at work might affect people with interstitial lung diseases (a group of lung conditions). Researchers will ask 1,000 adults with a new diagnosis about their exposures to things like pollution, chemicals, and dust. The goal is …

This study watches how a high-frequency ventilator (Servo-n HFOV) works in real hospital use for babies with severe breathing failure. About 75 infants will be observed to see if the machine safely helps them get enough oxygen and remove carbon dioxide. The goal is to gather info…

This study is observing brain oxygen levels in two groups of newborns at high risk of brain injury: full-term babies undergoing cooling treatment for oxygen deprivation, and extremely premature babies. Researchers use a non-invasive light sensor (near-infrared spectroscopy) to me…

This study aims to see if a simple, non-invasive breathing test can accurately measure the acidity (pH) in the airways, which is often abnormal in lung diseases. Researchers will compare results from this breath test with standard methods in 150 healthy volunteers and people with…

This study watches 200 people with lung, gut, or hormone diseases over time using special brain scans (PET). It aims to see how these diseases change brain activity and whether those changes can predict tumor return, spread, or survival. No new treatment is tested—just observatio…