Respiratory distress syndrome in premature infants
MONDO:0009971Infant acute respiratory distress syndrome is a lung disorder that affects premature infants caused by developmental insufficiency of surfactant production and structural immaturity of the lungs. The symptoms usually appear shortly after birth and may include tachypnea, tachycardia, chest wall retractions (recession), expiratory grunting, nasal flaring and cyanosis during breathing efforts.
Also known as: RDS, respiratory distress syndrome, RDS of prematurity, Respiratory Distress Syndrome, Infant, respiratory distress syndrome in premature infants, IRDS, NRDS, RDS - infants
178 clinical trials for this condition and its sub-types.
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Could a second dose of steroids help premature babies breathe easier?
Disease control TerminatedThis study investigates whether giving a repeat course of betamethasone, a steroid, to pregnant women with preterm premature rupture of membranes (PPROM) can improve health outcomes for their premature babies. The main goal is to see if it shortens the baby's stay in the neonatal…
Phase: PHASE2, PHASE3 • Sponsor: The University of Texas Medical Branch, Galveston • Aim: Disease control
Last updated Jul 02, 2026 00:00 UTC
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Lung disease drug trial in kids halted early
Disease control TerminatedThis study tested whether hydroxychloroquine could help children with a rare lung condition called interstitial lung disease. About 35 children were planned to take either the drug or a placebo to see if their oxygen levels or breathing improved. The trial was stopped early, so r…
Phase: PHASE2 • Sponsor: Matthias Griese • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC
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Musical pacifier may help preemies with lung disease eat sooner
Symptom relief TerminatedThis study tested a special pacifier that plays music or a mother's voice when a baby sucks correctly. It aimed to help premature infants with chronic lung disease learn to feed by mouth more quickly. The trial enrolled 33 babies but was stopped early, so the results are not conc…
Phase: NA • Sponsor: University of Missouri-Columbia • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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Tiny study on lung support in ARDS halted early
Knowledge-focused TerminatedThis study aimed to compare two ways of setting breathing machine pressure (PEEP) in patients with severe lung injury (ARDS). The goal was to see which method better protects the lungs and heart. Only 2 patients were enrolled before the study was stopped, so no meaningful results…
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC