Pulmonary non-tuberculous mycobacterial infection

This study tests whether adding delpazolid to standard treatment can reduce bacterial levels in people with hard-to-treat Mycobacterium abscessus lung infections. Participants take delpazolid tablets daily for 12 weeks, with the option to continue up to one year if there is clini…

This study tested whether adding bedaquiline to two standard antibiotics (clarithromycin and ethambutol) helps clear a stubborn lung infection called MAC lung disease. 129 adults who had not responded to previous treatment took part. The main goal was to see if the new combinatio…

This study tested whether taking two antibiotics instead of three is just as effective for treating a lung infection called MAC, while causing fewer side effects. 474 adults with MAC lung disease were randomly assigned to receive either two or three drugs for 12 months. The goal …

This study tested an experimental drug called SPR720 in 25 adults with a chronic lung infection caused by Mycobacterium avium complex (MAC). The goal was to see if the drug can reduce bacteria in sputum and is safe compared to a placebo. Participants took the drug or placebo by m…

This study tested whether giving general practitioners a rapid C-reactive protein (CRP) test helps them decide when antibiotics are truly needed for patients with respiratory infections. 140 patients with symptoms like cough, fever, or sore throat took part. Doctors in the test g…

This study looked at whether FebriDx, a rapid fingerstick test, can accurately tell bacterial from non-bacterial acute respiratory infections when used by people without lab training. Researchers compared results from untrained operators to trained ones in 800 patients with fever…

This study tested whether a smartwatch app called Hyfe can accurately count how often people cough. Researchers compared the app's cough counts to manual counts from audio recordings in 31 adults with various cough-related conditions. The goal is to see if the smartwatch can be a…

This study is testing a hypertonic seawater aerosol spray (a saltwater mist) to see if it helps relieve nasal symptoms, improve sleep, and thin mucus in people with colds, sinus infections, or similar upper respiratory infections. About 110 adults and children aged 2 and older wi…

This study looked at different ways to collect sputum (phlegm) from people with a lung infection called nontuberculous mycobacterial (NTM) infection. The goal was to see which method gives the best samples for diagnosing and understanding the infection. Participants provided thro…

This pilot study looked at how well the antibiotic azithromycin kills Mycobacterium avium complex (MAC) bacteria in the lungs during the first 14 days of treatment. Ten adults with MAC lung disease took azithromycin daily, and researchers measured bacterial levels in their sputum…

This completed study looked at people with genetic conditions that affect how the lungs clear mucus, such as cystic fibrosis and primary ciliary dyskinesia. Researchers examined 87 participants, including healthy volunteers, to understand why these patients get repeated lung infe…

This study examined 41 patients treated for non-tuberculous mycobacteria (NTM) infections, comparing those with and without cancer. The goal was to count side effects from NTM treatment in each group to understand why cancer patients often stop therapy. Researchers hope this will…

This study looked at 537 patients with respiratory infection symptoms to see how the types of viruses and bacteria changed from the COVID-19 pandemic period to after it. Researchers used a special PCR test to detect multiple germs at once. The goal was to understand how pandemic …

This study checked how accurate a new test (Xpert Expanded Respiratory Panel) is at finding respiratory infections. Researchers tested nose swabs from 3,200 people with symptoms and compared results to other tests. The goal was to see if the new test works well enough for routine…

This study tested whether adding infectious disease experts to primary care teams helps reduce unnecessary antibiotic use. Over 1,300 patients from six clinics in Spain took part. Doctors in the expert-advised group could call or meet with specialists to discuss tricky cases. The…

This study tested a program to help doctors prescribe antibiotics more appropriately for common childhood infections like earaches, sore throats, and sinusitis. Over 1,000 doctors took part, receiving online training, personalized feedback on their prescribing habits, and support…

This study tested a computer tool that helps nurses decide when antibiotics are needed for common respiratory infections like colds and sore throats. The tool, built into the electronic health record, calculates a patient's risk and suggests appropriate care. Researchers measured…

This study tested a smartphone app called Hyfe Cough Tracker to see if it can accurately count coughs in people with lung conditions like COPD, asthma, or COVID-19. Researchers compared the app's cough counts to patients' own reports and expert listening. The goal was to improve …

This completed study looked at how a special form of vitamin B3 (nicotinamide) is processed in 28 patients with low tryptophan levels due to respiratory infections or inflammatory bowel disease. Participants took either 500 mg or 1000 mg of the supplement daily for four weeks. Th…