Pulmonary emphysema

This study tests whether weekly infusions of Alpha-1 MP (a protein replacement) can slow lung damage in 345 people with emphysema caused by Alpha-1 antitrypsin deficiency. Participants receive one of two doses or a placebo for three years, with lung CT scans tracking changes. The…

This study looks at the long-term safety of a weekly intravenous treatment for people with emphysema caused by alpha-1 antitrypsin deficiency. About 290 adults who completed a prior study will receive the drug for 2 more years. The main goal is to monitor side effects, not to cur…

This study tests a new drug called verekitug in 666 people with moderate-to-severe COPD, a long-term lung disease that makes breathing hard. The goal is to see if it can reduce serious flare-ups and improve lung function compared to a placebo. Participants must be current or form…

This study tests a new drug called SAR447537 (INBRX-101) in 185 adults with alpha-1 antitrypsin deficiency (AATD) emphysema, a genetic condition that causes lung damage. The drug is a lab-made protein designed to replace the missing enzyme and slow disease progression. The main g…

This study tests a new device called the Apreo Implant, which is placed in the airways during a bronchoscopy to release trapped air in severely overinflated lungs. Up to 30 people with severe emphysema will receive up to two procedures, with follow-up for one year. The main goals…

This early trial is testing a device called the Implantable Artificial Bronchus (IAB) in 20 adults with COPD or emphysema. The device is placed in the airways using a bronchoscope to relieve lung overinflation and improve airflow. The main goal is to check safety, looking for ser…

This study tests whether doxycycline, an antibiotic, can slow the worsening of emphysema in people living with HIV. About 133 current or former smokers with HIV will take doxycycline for 72 weeks. Researchers will measure lung function, walking ability, and check for antibiotic r…

This study tests whether stem cells taken from a person's own belly fat can safely help treat chronic lung diseases like COPD. About 100 adults with moderate to severe COPD will receive their own processed cells through an IV. The main goal is to check safety and see if lung func…

This study tests whether using a breathing muscle training device, along with standard physical therapy, helps people recover more quickly after a lung transplant. About 90 adults waiting for a lung transplant will take part. The goal is to see if this training improves breathing…

This study looks at how changing the pressure inside a breathing machine affects lung function in 20 patients with obstructive airway diseases who are on full ventilator support. Researchers will test different pressure levels to see how they impact gas exchange and how the lungs…

This large real-world study will follow 10,000 Italian patients with COPD to see how their treatments, flare-ups, and other health conditions affect their risk of death. Researchers will collect data on medications, lung function, and heart problems over time. The goal is to bett…

This study explores how problems with blood vessel function and genetics may contribute to early-stage COPD and emphysema. Researchers followed over 4,300 adults from a larger heart study, measuring lung function and CT scans. The goal is to understand risk factors, not to test a…

This study is testing whether a breathing test called the lung clearance index (LCI) can detect small airways disease in adults with chronic lung conditions like asthma or fibrosis. Researchers will compare results from 300 patients with lung disease to 300 healthy volunteers. Th…

This study is looking for early signs of lung cancer in people at high risk, such as older smokers or those with COPD. Researchers will collect blood and airway samples from 665 participants to find biomarkers that could predict lung cancer before symptoms appear. The goal is to …

This study aims to see if a simple, non-invasive breathing test can accurately measure the acidity (pH) in the airways, which is often abnormal in lung diseases. Researchers will compare results from this breath test with standard methods in 150 healthy volunteers and people with…

This study follows nearly 3,000 people with COPD (a chronic lung disease) over several years to understand how the disease progresses and what factors influence it. Researchers measure lung function, analyze mucus, and track environmental exposures like air pollution. The goal is…

This study watches 200 people with lung, gut, or hormone diseases over time using special brain scans (PET). It aims to see how these diseases change brain activity and whether those changes can predict tumor return, spread, or survival. No new treatment is tested—just observatio…

This study is looking at over 10,000 smokers to find out if certain genes make some people more likely to develop COPD, a serious long-term lung disease. Participants are having their lung function tested and getting chest CT scans. The goal is to understand why some smokers get …