Pregnancy disorder with abortive outcome

Thick meconium in the amniotic fluid affects about 1 in 7 pregnancies and can cause breathing problems in newborns. The PEARL trial tests whether infusing warm sterile fluid into the uterus during labor reduces these risks. The study will enroll 320 pregnant people at 36 weeks or…

This study looks at different treatments for early missed abortion, where a pregnancy stops developing but the body doesn't expel the tissue. Researchers will compare surgery and medication, and also test if adding estrogen helps. The goal is to find the safest and most effective…

This study tests whether treating asymptomatic bacteriuria (a bladder infection with no symptoms) in pregnant women can reduce the number of preterm births, stillbirths, and underweight babies. Over 1,100 pregnant women in seven low- and middle-income countries will receive eithe…

This study tests whether taking 150 mg of aspirin daily, starting before 20 weeks of pregnancy, can prevent serious problems like preeclampsia, poor fetal growth, placental abruption, preterm birth, and death in pregnant women with chronic high blood pressure. About 500 women wil…

This study looks at whether a structured ultrasound program (OxGRIP) can help detect babies that are not growing well in the womb, which is a major risk factor for stillbirth. The program adds a routine scan at 36 weeks and extra scans for at-risk women. Researchers will compare …

This study tests whether starting a higher dose of aspirin very early in pregnancy (before 7 weeks) can lower the risk of preeclampsia and pregnancy loss in women with risk factors. About 1,150 pregnant women will take either 162 mg of aspirin daily or a placebo followed by stand…

This study looks at whether coloring mandalas can lower stress, anxiety, and pain in women who have a missed abortion (a pregnancy loss before 10 weeks). About 126 women will be randomly assigned to either color mandalas or receive standard care. Researchers will measure changes …

This study is testing two new ultrasound techniques to see if they can tell the difference between healthy pregnancies and those affected by fetal growth restriction (FGR), where the baby is smaller than expected. Researchers will scan 60 pregnant women every three weeks using a …

This study is testing a unified first trimester screening approach to predict serious pregnancy complications like preeclampsia, fetal growth restriction, and birth defects. Researchers will enroll 2,000 pregnant women in the Czech Republic to see if combining standard tests can …

This study aims to find genetic factors that may cause repeated miscarriages or unexplained fetal deaths. Researchers will collect biological samples from 200 couples who have experienced at least three early miscarriages or a fetal death in the second or third trimester. By comp…

This study looks at a special antenatal clinic called the Rainbow Clinic, designed for women who have previously experienced stillbirth or neonatal death. Researchers will track pregnancy outcomes and measure anxiety and depression in 500 women attending these clinics across the …

This study is testing a new, non-invasive monitor (fetal magnetocardiography) to detect hidden heart problems in high-risk pregnancies that might lead to fetal death. Researchers will study 30 pregnant women with conditions like congenital heart disease or twin pregnancy. The goa…

This study aims to find factors that can be changed to prevent stillbirths between 20 and 28 weeks of pregnancy. Researchers will compare 316 mothers who experienced an early stillbirth with 632 mothers with healthy pregnancies, using questionnaires about sleep, diet, and care. T…

This study is gathering information from 640 pregnant people to build a computer model that can predict placental insufficiency — a condition where the placenta doesn't work well and can lead to stillbirth. Participants will have extra ultrasounds and blood tests during pregnancy…

This study tests a two-way SMS system that lets pregnant women in Kenya text community health volunteers about their newborn's health. The goal is to see if this quick communication can reduce deaths in the first month of life. About 3000 women will take part, and the results cou…