Pancreas disorder

This trial tests whether two approved drugs, dabrafenib and trametinib, can treat rare cancers that have a specific genetic change called BRAF V600. These drugs are already used for melanoma and lung cancer, but researchers want to see if they help people with other cancer types.…

This study tests whether rinsing the bile duct opening with cold water, in addition to standard rectal indomethacin, can better prevent pancreatitis after ERCP—a common procedure to treat bile or pancreas issues. About 150 adults in India will be randomly assigned to get either t…

This study tests whether fecal microbiota transplantation (FMT) — transferring gut bacteria from healthy donors — can prevent infections in people with moderately severe or severe acute pancreatitis. About 150 adults will receive either FMT liquid or a placebo through a feeding t…

This study tests whether ondansetron, a drug often used for nausea, can prevent pancreatitis (inflammation of the pancreas) after a procedure called ERCP. About 44 adults who need this procedure will receive ondansetron or a placebo. The main goal is to see if fewer people develo…

This study compares deep sedation (using a breathing tube in the nose) with general anesthesia (using a tube down the throat) in 170 patients aged 60 and older undergoing ERCP, a procedure to treat bile duct or pancreas problems. The goal is to see which method causes fewer breat…

Researchers are creating a biobank of biological samples and clinical data from 2000 adults with various pancreatic conditions, including pancreatitis and pancreatic cancer. The goal is to investigate how genetic predisposition and environmental exposures interact to trigger thes…

This study looks at whether people who carry one copy of the cystic fibrosis gene (CF carriers) have early signs of kidney or pancreas problems. Researchers will compare 1250 CF carriers and non-carriers using blood tests, urine and stool samples, and surveys. The goal is to see …

This study is looking at why some people with advanced cancer lose weight and muscle, a condition called cachexia. Researchers will follow 800 patients with advanced lung, pancreatic, or colorectal cancer to see if there are distinct subtypes of cachexia based on symptoms, biomar…

This study aims to create a simple, minimally invasive test to find pancreatic cancer at an early stage and track how well treatment is working. Researchers will study 700 people with pancreatic cancer, pancreatitis, or pancreatic cysts. The goal is to identify biological markers…

This study reviews medical records of 500 adults treated for benign or malignant pancreatic diseases since 2005. The goal is to understand how well different treatments worked over time. No new treatments are given—just careful analysis of past cases.

This study is creating a detailed record of 6,000 adults who had an ERCP procedure for bile duct or pancreas problems. Researchers are collecting information before, during, and after the procedure to track complications like pancreatitis or bleeding. The goal is to better unders…

This study collects blood, tissue, and health information from 20,000 people with pancreas diseases like pancreatic cancer, pancreatitis, or cysts. The goal is to create a large database and sample bank that researchers can use to better understand these conditions and develop be…

This study tracks 1,000 patients undergoing major liver, pancreas, or bile duct surgery to see if the time it takes for their albumin levels to return to normal can predict complications and length of hospital stay. Albumin is a protein that drops after surgery due to inflammatio…

This study is looking for new biomarkers to tell which pancreatic cysts (IPMNs) are likely to become cancerous. Researchers will analyze genetic, metabolic, and lifestyle data from 800 patients to develop a risk score. The goal is to help doctors decide who truly needs surgery an…

This study follows 4,000 adults aged 30 and older who have at least one pancreatic cyst, a common finding on scans. Researchers will track changes over time using surveys and medical records to see which cysts turn into cancer. The goal is to better tell harmless cysts from dange…