Osteonecrosis of the jaw

This study investigates whether a patient's own platelet concentrate, called A-PRF, can improve early wound healing after tooth extraction in people at high risk for medication-related osteonecrosis of the jaw (MRONJ). Participants are adults who have taken or are taking bone-str…

This study tests whether a substance made from a patient's own blood, called platelet-rich fibrin (L-PRF), can prevent a serious condition called jawbone death after tooth extraction. The trial will include 40 people at high risk due to past radiation or certain medications. Half…

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This study compares two surgical techniques for treating medication-related osteonecrosis of the jaw (MRONJ), a condition where jawbone dies due to certain drugs. Thirty-four adults with stage 1 or 2 MRONJ will be randomly assigned to receive either traditional rotary instrument …

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This study will look at how jaw bone quality changes over time in patients with medication-related osteonecrosis of the jaw (MRONJ), a side effect of drugs like bisphosphonates. Researchers will analyze existing CBCT scans from 25 adults to measure bone density and structure at d…

This study looks at patients who develop a condition called MRONJ (bone death in the jaw) after taking osteoporosis medications. When this happens around a dental implant, doctors disagree on whether to remove the implant or try to save it. The study will compare healing and bone…

This study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…