Osteonecrosis of genetic origin

This early study is testing a new device called the ReNew Hip Implant in 15 people aged 14 to 64 with hip cartilage damage from conditions like osteoarthritis or hip impingement. The implant is surgically placed to repair the cartilage. Researchers are checking if it is safe and …

This trial tests whether a small metal implant, called the Episealer Talus, can relieve pain and improve function in people with a specific type of ankle cartilage damage. The study will enroll 20 adults aged 18 to 65 who have a focal defect on the talus bone and have not improve…

This study is testing a new hip implant called the OR3O Dual Mobility System in 177 people who need hip replacement surgery. The goal is to see if the implant is safe and lasts longer without needing another surgery. Researchers will follow participants for up to 10 years to chec…

This early-stage study tests a single intravenous dose of a gene therapy called LY3884961 in 15 adults with Gaucher disease type 1. The goal is to see if it is safe and can reduce or replace the need for ongoing enzyme replacement or substrate reduction therapy. Participants must…

This study is testing a new type of hip resurfacing device made entirely of ceramic, designed for people with hip osteoarthritis, necrosis, or dysplasia. The goal is to see if it is as safe and effective as existing metal-on-metal devices, but without releasing metal ions into th…

This early-phase trial tests a single intravenous dose of LY-M001 gene therapy in 9 children (ages 6 to 17) with type 1 Gaucher disease. The goal is to see if it is safe and can improve key symptoms like liver size and blood markers. Researchers will monitor participants for side…

This study looks at how well a surgical technique called AMIC holds up ten years after repairing cartilage damage in the ankle. Researchers are checking whether the pain relief and function patients gained in the first few years remain stable or fade over time. About 40 people wh…

This study follows 300 people who receive a hip replacement using either the Vivacit-E or Longevity liner, both made of a special plastic designed to last longer. The goal is to see how well these liners hold up over time, measuring how many are still in place without needing rep…

This phase 2 trial tests an oral drug called venglustat, given alongside the standard enzyme therapy Cerezyme, in adults with Gaucher disease type 3 (a rare genetic disorder affecting the body and brain). The study has four parts: first, it checks spinal fluid biomarkers to disti…

This study planned to test a new hip replacement device (the HYPE stem) in people with hip arthritis or other hip damage. The goal was to see how well the device works and if it is safe. However, the study was withdrawn before any participants were enrolled, so no results are ava…

This study tests a treatment using stem cells from donated umbilical cords for people with early-stage osteonecrosis (bone death) of the hip. The goal is to see if the cells are safe and can help control the disease, possibly avoiding the need for hip replacement. The study was s…

This study tests a procedure for people with early-stage osteonecrosis (bone death) of the hip. Doctors drill into the hip bone, inject a concentrated sample of the patient's own bone marrow, and add a special bone graft material called Genex. The goal is to see if this helps bon…

This study follows 52 people who already received a Vivacit-E hip liner during total hip replacement. Researchers will track how long the implant lasts and any problems over 10 years. The goal is to confirm the liner is safe and helps reduce pain and improve movement for conditio…

This study tests a new drug called RAB001 in people with early-stage hip bone damage caused by long-term steroid use. About 160 participants will receive either a low, medium, or high dose of RAB001, or a standard bone drug (alendronate). The goal is to see if RAB001 can reduce t…

This study looks at the safety and performance of a cemented hip stem (TrendHip®) in 119 people who had hip replacement surgery. It tracks pain, function, and quality of life for up to 5 years after surgery. The goal is to confirm the device works well in everyday use.

This study follows 102 people who received the aneXys hip replacement cup to see how safe and effective it is over 2 years. Researchers measure if the cup moves and track pain and function using standard scores. The goal is to confirm the device works well in everyday use.

This study tests a new way to repair damaged knee cartilage using 3D printing, platelet-rich plasma, and a piece of the patient's own bone and tissue. It involves 60 adults with large cartilage injuries. The goal is to see if this approach improves knee function and helps cartila…

This study tests a new coating on a hip replacement implant that may help prevent infections and help the implant bond better with the bone. About 340 adults needing a hip replacement will receive either the coated or standard implant. The goal is to see if the coated implant wor…

This study tracks 100 adults who need a hip replacement to see how well the Avenir cemented hip stem works and holds up over time. Participants have conditions like arthritis, hip fractures, or hip damage from past surgeries. The main goal is to measure how long the implant lasts…

This study follows 75 people with Gaucher disease type 1 who previously received FLT201 gene therapy. Researchers will monitor them for 5 years to see if the treatment remains safe and if its effects last. The goal is to understand whether a single dose can provide long-term dise…

This study is tracking 100 people who received a total hip replacement with a specific implant called AMIStem C. The main goal is to see how much the implant moves inside the bone over time, using special X-ray analysis. Researchers will also check how well patients recover and h…

This study follows 300 adults aged 18-75 who received a specific type of hip implant (Quadra-P stem) during hip replacement surgery. The goal is to see how well the implant works over 10 years, including how long it lasts and how it improves pain and movement. Participants have c…

This study tests if adding two extra nerve blocks to a standard one can improve pain control and recovery after hip replacement surgery. About 60 adults having hip surgery will be randomly assigned to receive either the standard block alone or the standard block plus the extra bl…

Researchers are reviewing past spinal fusion surgeries to see if patient-specific guides, called MySpine, place screws safely even in the most challenging bone. They will compare nerve irritation rates between standard screws and those in anatomically complex positions, known as …

This registry follows patients who receive donor cartilage or meniscus transplants for joint defects in the knee, hip, ankle, or shoulder. Researchers are collecting long-term data on pain, function, and whether the grafts need revision or fail over time. The goal is to understan…

This study looks at over 110,000 people who had hip replacement surgery to see if a longer or shorter hip stem works better. It compares death rates, how often the hip implant needs to be replaced, and patient-reported pain and function. The goal is to find out which stem length …

This study looks at whether giving doctors a patient's genetic information can help them personalize chemotherapy doses and reduce serious side effects. About 860 adults with certain cancers (like breast, stomach, or head and neck) will be randomly assigned to have their doctors …

This study is observing 60 people who received a special hip replacement cup (Plasmafit Revision Structan) during routine surgery. Researchers are checking how well the cup works and how long it lasts by tracking hip function and any need for repeat surgery. No new treatment is b…

This study was designed to test a new tool that helps surgeons measure and adjust the spine during fusion surgery. The goal was to see if using the tool leads to better spinal alignment and improved patient outcomes, such as less disability. However, the study was withdrawn befor…

This study looks at how a knee condition called osteochondritis dissecans (OCD) affects the mental health of young athletes aged 11 to 19. Researchers will measure stress and depression levels in 120 patients as they go through standard treatment, either surgery or non-surgical c…

This study looks at how well treatments for childhood hip conditions (like hip dysplasia and Perthes disease) work over the long term. Researchers at Mayo Clinic are following 500 adults who were treated for these conditions as children. They will check how many needed another su…

This study follows 248 adults receiving a CoreHip hip replacement to see how their hip function, pain, and leg length change over time. Participants are treated as part of routine care, and no extra tests or treatments are given. The goal is to collect real-world data on the impl…

This study looks at 254 people with a knee condition where a piece of bone and cartilage starts to crack and loosen. Researchers are observing how well different standard treatments—like rest or surgery—work over two years. The goal is to learn which approach leads to better knee…

This study asks over 2,300 people with various joint conditions (like arthritis, fractures, and hip problems) to fill out surveys about their treatment preferences. Researchers want to learn how factors like pain, recovery time, cost, and surgery versus non-surgery affect patient…

This study looks at how people walk before and after a type of ankle surgery called arthroscopic microfracture with a biologic scaffold. The surgery is used to repair damaged cartilage in the ankle joint. Researchers will measure foot pressure and walking patterns in 60 patients …