Osteochondrosis

This trial tests whether virtual reality-based posture training, using a Meta Quest 3 headset, can improve the spine curvature (kyphotic angle) and quality of life in adolescents aged 13 to 18 with thoracic hyperkyphosis (a rounded upper back). Participants will receive a 12-week…

This study tests whether alendronate, a drug used for osteoporosis, can help adults with sickle cell disease who have bone damage (osteonecrosis). Thirty participants will take a weekly pill for 24 weeks. The main goals are to see if the treatment is feasible and safe, and to mea…

This study follows 200 scoliosis patients who have received the Ennovate Complex implant to see how safe and effective it is over time. Researchers will track changes in pain and quality of life using standard questionnaires. The goal is to confirm the device works well in real-w…

This study tests whether 3D-printed models and custom surgical guides can help surgeons better plan and perform wrist bone cuts for Kienbock's disease (stages II and III). About 20 adults will receive the 3D-assisted surgery, and researchers will measure pain, wrist function, and…

This pilot study is testing a custom-made, 3D-printed titanium implant that replaces the ankle joint and talus bone in people with severe bone loss or damage. The implant is designed to fit each patient perfectly and aims to preserve ankle function while reducing surgical harm to…

This study is testing a procedure called autologous chondrocyte implantation (ACI) for people with knee cartilage defects. Doctors take a sample of the patient's own cartilage cells, grow them in a lab, and then implant them into the damaged area. The goal is to see if this appro…

This early study is testing a new device called the ReNew Hip Implant in 15 people aged 14 to 64 with hip cartilage damage from conditions like osteoarthritis or hip impingement. The implant is surgically placed to repair the cartilage. Researchers are checking if it is safe and …

This study tests a different chemotherapy drug (trifluridine/tipiracil) for people with metastatic colorectal or gastroesophageal cancer who have a genetic condition (DPD deficiency) that makes standard chemo very toxic. About 73 participants will receive this drug along with oth…

This study tests whether adding a patient's own concentrated bone marrow cells to a standard hip surgery (core decompression) can prevent the hip ball from collapsing and delay or avoid the need for a hip replacement. It includes 192 adults with early-stage osteonecrosis (before …

This study is looking for substances in the blood that can help doctors diagnose osteonecrosis of the femoral head (a condition where the hip bone dies) much earlier. Currently, many cases are missed or misdiagnosed. Researchers will collect blood from 300 people with suspected h…

This study tests a 12-week individualized rehabilitation program for youth athletes aged 10–17 with Osgood-Schlatter disease (knee pain) or Sever disease (heel pain). The program includes education, pain monitoring, and tailored exercises. Researchers want to see if it's feasible…

This study tests whether low-level laser therapy (a painless light treatment) can reduce knee or heel pain in active kids aged 10–17 with Osgood-Schlatter or Sever disease. About 30 young athletes will receive either real laser or a sham (fake) treatment over two weeks. Researche…

This study tests if Schroth exercises, a special type of physical therapy, can improve shoulder muscle function in children aged 7-18 with a rounded upper back (thoracic hyperkyphosis). 56 participants will either do these exercises for 8 weeks or receive standard posture educati…

This study tests whether adding kinesiotaping (a special elastic tape) to exercise can improve posture, balance, pain, and quality of life in young adults aged 18-45 with a rounded upper back (thoracic hyperkyphosis). 48 participants will be split into three groups: exercise plus…

This study compares hatha yoga and reformer pilates to see which better improves posture, pain, balance, and quality of life in 30 people with hyperkyphosis (excessive rounding of the upper back). Participants will be assigned to one of three groups: yoga, pilates, or home exerci…

This study aims to learn more about rare disorders that affect how the body processes chemicals called pyrimidines and purines. These disorders can cause problems in the brain, blood, kidneys, and immune system, ranging from mild to life-threatening. Researchers will compare test…