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New hope for cancer patients with dangerous gene flaw: safer chemo combo tested

NCT ID NCT06245356

Recruiting now Disease control Sponsor: UNICANCER Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a different chemotherapy drug (trifluridine/tipiracil) for people with metastatic colorectal or gastroesophageal cancer who have a genetic condition (DPD deficiency) that makes standard chemo very toxic. About 73 participants will receive this drug along with other targeted therapies. The main goal is to see if this approach causes fewer severe side effects like diarrhea, mouth sores, and dangerous drops in white blood cells.

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Conditions

The condition(s) this trial relates to.

colorectal adenocarcinoma colorectal cancer colorectal neoplasm dihydropyrimidine dehydrogenase deficiency gastroesophageal adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DPD DEFICIENCY METASTATIC COLORECTAL CANCER METASTATIC GASTROESOPHAGEAL ADENOCARCINOMA

Contacts and locations

Locations

  • CH de Saint-Malo

    ACTIVE_NOT_RECRUITING

    St-Malo, 35403, France

  • CHU Amiens

    NOT_YET_RECRUITING

    Amiens, 80054, France

  • CHU Jean Minjoz

    ACTIVE_NOT_RECRUITING

    Besançon, 25000, France

  • CHU Saint-Etienne

    ACTIVE_NOT_RECRUITING

    Saint-Priest-en-Jarez, 42270, France

  • CHU de Poitiers

    ACTIVE_NOT_RECRUITING

    Poitiers, 86000, France

  • CHU de REIMS

    ACTIVE_NOT_RECRUITING

    Reims, 51092, France

  • Centre Georges François Leclerc

    WITHDRAWN

    Dijon, 21079, France

  • Centre Hospitalier de Cholet

    ACTIVE_NOT_RECRUITING

    Cholet, 49300, France

  • Hospices Civils de Lyon

    ACTIVE_NOT_RECRUITING

    Pierre-Bénite, 69495, France

  • Hôpital Cochin

    ACTIVE_NOT_RECRUITING

    Paris, 75014, France

  • Hôpital Nord Franche-Comté / Site du Mittan

    ACTIVE_NOT_RECRUITING

    Trévenans, 90400, France

  • Hôpital Privé Jean Mermoz

    ACTIVE_NOT_RECRUITING

    Lyon, 69008, France

  • Hôpital Saint Antoine

    RECRUITING

    Paris, 75012, France

  • Hôpital Saint Louis

    ACTIVE_NOT_RECRUITING

    Paris, 75010, France

  • Hôpital des Diaconesses Croix Saint Simon

    ACTIVE_NOT_RECRUITING

    Paris, 75960, France

  • Institut Godinot

    RECRUITING

    Reims, 51100, France

  • Institut Régional du Cancer de Montpellier - ICM Val d'Aurelle

    RECRUITING

    Montpellier, 34298, France

  • Institut de Cancérologie de Lorraine

    ACTIVE_NOT_RECRUITING

    Vandœuvre-lès-Nancy, 54519, France

  • Institut de Cancérologie de l'Ouest

    NOT_YET_RECRUITING

    Angers, 49055, France

  • Institut de Cancérologie de l'Ouest - Site René Gauducheau

    WITHDRAWN

    Saint-Herblain, France

  • Institut du Cancer d'Avignon

    ACTIVE_NOT_RECRUITING

    Avignon, 84918, France

More trials for these conditions

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