Lymphedema

This study tests a new dye called Magtrace that stays in the lymph nodes for weeks. For women with non-invasive breast cancer (DCIS) having a mastectomy, this dye may allow doctors to safely delay lymph node removal until after the breast tissue is checked for hidden invasive can…

This study compares a 1-week radiation course to a standard 3-week course for women with node-positive breast cancer. The goal is to see if the shorter treatment is just as effective at preventing cancer from coming back while reducing the risk of lymphedema (arm swelling). About…

This study tests whether closely monitoring arm swelling after breast cancer surgery and treating it early with a compression sleeve can prevent long-term lymphedema. 250 women who had many lymph nodes removed will be randomly assigned to either the monitoring program or usual ca…

This study tests a technique called axillary reverse mapping (ARM) to see if it can prevent lymphedema—painful arm swelling—after breast cancer surgery. About 534 people with stage I-III breast cancer will be followed for 3 years. The goal is to find out if mapping and preserving…

This study is testing a shorter, more intense radiation schedule (hypofractionation) for women with breast cancer who have had surgery. The goal is to see if this approach is safe and effective at preventing cancer from coming back while reducing side effects like arm swelling. F…

This study tests whether a surgical technique called immediate lymphatic reconstruction can prevent lymphedema (arm swelling) in breast cancer patients who need lymph node removal. About 180 women will be randomly assigned to receive either standard lymph node removal alone or wi…

This study tests a new ultrasound technique called SAVE that measures how stiff and fluid-filled arm tissues are in people with lymphedema. Researchers want to see if this method can accurately tell the difference between a swollen arm and a healthy one. If it works, it could hel…

This study uses a special camera and a safe dye to take pictures of the lymphatic system, which helps move fluid in the body. Researchers want to see how this system works in healthy people and in those with conditions like lymphedema or lipedema. The goal is to find patterns tha…

This study tests whether starting physiotherapy early—before any swelling appears—can prevent lymphedema in people treated for head and neck cancer. Twenty participants will either use a home compression device daily or receive standard care. Researchers will track swelling and u…

This study tests whether moving lymph nodes from one part of the body to the armpit during breast reconstruction can lower the risk of lymphedema, a painful arm swelling. Thirty breast cancer patients who had mastectomy and lymph node removal will receive the extra procedure. Res…

This study tests whether a mobile application can help breast cancer survivors prevent lymphedema, a common and often permanent swelling of the arm after surgery. Participants who had breast cancer surgery at least one month ago will be randomly assigned to use the app or receive…

This study tests whether a special surgical technique called Axillary Reverse Mapping (ARM) can prevent lymphedema (arm swelling) in breast cancer patients who need lymph node removal. The ARM technique aims to preserve the arm's lymph drainage during surgery. 100 patients will b…

This trial tests whether a live online exercise and self-drainage program can reduce arm swelling in women with breast cancer-related lymphedema. Researchers will compare women who join live video sessions with a therapist to those who follow the same program at home using a broc…

This study tests whether temporarily freezing the nerves that supply the breast can reduce pain and the need for opioid painkillers after mastectomy. About 216 women having breast removal will receive either the freezing treatment or a sham procedure. The goal is to see if a sing…

This study investigates whether adding diaphragmatic breathing exercises to standard manual lymphatic drainage (MLD) therapy reduces arm swelling and pain better than MLD alone in women who developed lymphedema after a radical mastectomy. Participants are female breast cancer sur…

This study tests a special massage technique called the Paloma Sahid Method to reduce leg swelling in women with lymphedema. Thirty-two women aged 30-65 with swelling in one leg will receive 12 sessions over one month. The goal is to see if this treatment improves leg size, funct…

This study compares two approaches to treating lymphedema (swelling) in people who have had head and neck cancer. One group gets all their therapy in a clinic, while the other starts with a few in-person sessions and then continues via video calls at home. The goal is to see if t…

This study aimed to compare two ways of numbing the chest after a mastectomy: a targeted nerve block versus direct injection into the surgical area. It was planned for adults aged 18-80 undergoing unilateral mastectomy. However, the trial was withdrawn before enrolling any partic…

This study asks breast cancer patients about their thoughts on screening for lymphedema, a common side effect where the arm becomes swollen and painful after treatment. Researchers use a device called a perometer to measure arm size before and after surgery. The goal is to see if…

This study follows 214 men treated for prostate cancer to see how many develop lower limb lymphedema (leg swelling) and who is most at risk. Participants attend check-ups every three months for 18 months. The goal is to better understand this side effect and its impact on quality…

This study looks back at the medical records of about 4 million people who had physical or occupational therapy for muscle and joint problems. Researchers want to see if different ways of giving therapy lead to different results. No new treatments are tested—the goal is to learn …

This study is collecting saliva, blood, and tissue from 100 adults with lymphedema to store for future research. The goal is to build a biorepository that can help scientists discover and validate biomarkers to improve microvascular treatment for lymphedema. Participants are not …

This study is testing a newly developed arm circumference measurement device for patients who may develop lymphedema after breast cancer surgery. Researchers want to see if the device is more accurate, faster, and easier to use than the traditional tape measure. The study involve…