Lipodystrophy

This study tested an experimental drug called REGN4461 in 16 people with generalized lipodystrophy, a rare condition where the body can't store fat properly, leading to severe metabolic problems. The drug aims to improve blood sugar and triglyceride levels. Participants received …

This study tested a visual injection site map to help people with diabetes rotate where they inject insulin. The goal was to reduce lipohypertrophy—lumpy fatty tissue caused by repeated shots in the same spot—and improve blood sugar control. 170 adults on insulin for at least six…

This study tested the drug spironolactone in 15 adults with chronic right-sided heart failure. The goal was to see if it is safe and can improve heart function and reduce stress on the heart. Participants took either the drug or a placebo to compare effects.

This study tested whether a new map for insulin injection sites (either digital or paper) could reduce skin lumps caused by insulin. 170 adults with diabetes who had been using insulin for at least six months took part. The map helped people rotate injection spots, aiming to impr…

This study looked at the safety of a daily shot called metreleptin (brand name Myalept) in 11 people with generalized lipodystrophy, a rare condition where the body loses fat tissue. The main goal was to see if the body makes antibodies against the drug, which could affect how we…

This completed study tested a dietary supplement called GLP-1 Booster in 69 overweight adults over 26 weeks. The supplement contains extracts from green tea, gardenia, turmeric, and other herbs, and is designed to increase the body's own GLP-1 hormone to help control blood sugar,…

This study tests whether ALIDYA, a gel injected into the skin, can improve the appearance of cellulite on the back of the thighs. Thirty women aged 20 to 45 with mild to moderate cellulite received six weekly treatments. Researchers used photos, ultrasound, and other imaging to m…

This study tested a medical device called ULTRACOL, a dissolvable implant placed under the skin, to see if it can safely improve wrinkles and other skin contour problems. 23 adults with facial wrinkles or skin aging took part. The main goal was to measure changes in wrinkle sever…

This study tested a gel-like implant (Algeness) to improve the look of wrinkles and other skin contour problems. 40 adults aged 30-65 with age-related skin changes took part. The main goal was to see if the implant reduced wrinkle severity on a standard scale. The study is comple…

This study looked for a new gene that causes hereditary lipodystrophy, a rare disease where people lose body fat and often develop diabetes and heart problems. Researchers studied DNA and cells from 2 patients who had the disease but no known genetic cause. The goal was to find t…

This completed study looked at 126 people with different fat distribution patterns—including those with lipodystrophy (abnormal fat loss or distribution), obesity, and normal weight—to understand how fat tissue relates to insulin resistance and immune signals. Researchers measure…

This study looked at whether it's safe to do liposuction at the same time as a tummy tuck (abdominoplasty). 63 adults were split into groups that had different amounts of skin lifting with or without liposuction. The goal was to see if the combination caused more complications li…

This study followed 56 people with HIV who had never taken HIV medication before. Researchers measured changes in body fat, heart function, and blood vessel health after starting treatment. The goal was to understand how HIV therapy might affect long-term heart and metabolic risk…

This study tested an artificial intelligence algorithm designed to help primary care doctors decide whether a patient with a skin condition really needs to see a dermatologist. Researchers enrolled 200 adults with skin problems and had their doctors take photos of the affected ar…

This study looked at how the body processes cortisol in people with a rare genetic condition called familial partial lipodystrophy type 2 (FPL2). The goal was to see if increased activity of a certain enzyme (11β-HSD1) contributes to the severe metabolic problems seen in this dis…

This study looked at how many girls and young women aged 11 to 20 with chronic diseases (like diabetes or immune conditions) got the HPV vaccine, compared to those without chronic illness. Researchers reviewed records of 223 participants from a hospital in France. The goal was to…

This completed study looked at 20 women who had large-volume liposuction (5–8 liters) to see how removing fat from different body surface areas affects hemoglobin, clotting, and electrolyte levels. The goal was to understand safety risks better. The study did not test a new treat…