Inherited orthostatic hypotension

This study tested different treatments for autonomic dysfunction, including POTS, in 381 adults with Long COVID. It compared non-drug approaches and medications to see which best eased symptoms like rapid heart rate and dizziness. The goal was to find effective ways to manage the…

This small pilot study tested whether mirabegron, a drug typically used for overactive bladder, can raise blood pressure and reduce fainting in people with POTS who have low blood pressure that standard treatments didn't help. Twenty adults took either 25 mg or 50 mg of the drug …

This pilot study tested whether a 12-week aquatic occupational therapy program could reduce symptoms and improve quality of life in people with Postural Orthostatic Tachycardia Syndrome (POTS). Five adults with POTS completed three 60-minute pool sessions per week, including gent…

This completed Phase 2 trial tested whether ivabradine, a drug that slows heart rate, can reduce symptoms like dizziness and rapid heartbeat in people with long COVID. 181 participants received either ivabradine or a placebo for 3 months, with follow-up for another 3 months. The …

This study tested a device that gently stimulates a nerve in the neck (called nVNS) to see if it can reduce symptoms like dizziness and fatigue in teenagers with POTS, a condition that causes a rapid heart rate upon standing. Forty teens with newly diagnosed POTS took part at May…

This study looks at tiny nerve fibers in the skin of people with Long COVID, POTS, diabetic neuropathy, and those who had COVID-19 without lasting symptoms. By comparing skin samples, researchers hope to find unique patterns that help explain ongoing symptoms like pain and dizzin…

This completed Phase 1 study at Vanderbilt University looked at how the renin-angiotensin-aldosterone system works in people with POTS, a condition that causes a rapid heart rate and dizziness upon standing. Researchers gave 28 participants (including healthy controls) a one-hour…