Experimental POTS drug targets racing heart in first human test

NCT ID NCT06593600

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tests a single dose of an experimental drug called REGN7544 in 82 people with Postural Orthostatic Tachycardia Syndrome (POTS). The goal is to see if the drug safely reduces the rapid heart rate that happens when standing up. Researchers will also check for side effects and how the drug moves through the body.

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Conditions

The condition(s) this trial relates to.

Orthostatic Intolerance postural orthostatic tachycardia syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • Indiana University Health Neuroscience Center

    Indianapolis, Indiana, 46202, United States

  • Innovative Research of West Florida, Inc.

    Clearwater, Florida, 33756, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Mercy Gilbert Medical Center

    Gilbert, Arizona, 85297, United States

  • New York University Langone

    New York, New York, 10016, United States

  • North County Neurology Associates

    Carlsbad, California, 92011, United States

  • Saint Luke's MidAmerica Heart Institute

    Kansas City, Missouri, 64111, United States

  • Southern California Heart Specialists

    Pasadena, California, 91105, United States

  • Stanford University

    Palo Alto, California, 94304, United States

  • University of Calgary

    Calgary, Alberta, T2N 4Z6, Canada

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, 73104, United States

  • University of Texas Southwestern

    Dallas, Texas, 75390, United States

  • University of Utah

    Salt Lake City, Utah, 84108, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

  • Yale University

    New Haven, Connecticut, 06511, United States