POTS puzzle: scientists probe blood pressure hormone link

NCT ID NCT00962949

Completed Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This completed Phase 1 study at Vanderbilt University looked at how the renin-angiotensin-aldosterone system works in people with POTS, a condition that causes a rapid heart rate and dizziness upon standing. Researchers gave 28 participants (including healthy controls) a one-hour infusion of angiotensin II to measure changes in blood pressure and hormone levels. The goal was to better understand the disease process, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Angiotensin II
What this could lead to: If successful, this study could help explain why people with POTS have trouble regulating blood pressure and heart rate when standing.
What could go wrong: This is a small, early-phase study with only 28 participants, so results may not apply to everyone with POTS. It is designed to understand the disease, not to test a treatment.

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Conditions

The condition(s) this trial relates to.

Orthostatic Intolerance postural orthostatic tachycardia syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME (POTS)

Contacts and locations

Locations

Vanderbilt University

Nashville, Tennessee, 37232, United States

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