Infectious colitis

This study tests new versions of a vaccine to prevent severe diarrhea caused by the C. diff germ. Healthy adults aged 50 and older who have never had a C. diff infection will receive either a new vaccine formula, a previously studied formula, or a placebo. The goal is to see whic…

This study tests a support program for teens aged 16-17.5 with Crohn's disease or ulcerative colitis as they move from pediatric to adult healthcare. The program includes personalized assessments, a transition navigator, and virtual skill-building sessions. Researchers will measu…

This study tests whether a fecal transplant (FMT) can safely and effectively treat recurrent C. difficile infections in children, including those with inflammatory bowel disease (IBD). Researchers will give FMT to 250 children aged 3-21 and track whether the infection comes back.…

This study tests an oral enzyme called SYN-004 in adults who have received a stem cell transplant and need intravenous antibiotics for fever. The enzyme is designed to break down antibiotics in the gut, protecting the natural bacteria there. Researchers will check safety, whether…

This study tests whether giving a probiotic (Saccharomyces boulardii) along with a common antibiotic can protect the gut bacteria of children aged 4 to 12 being treated for ear or sinus infections. The goal is to see if it reduces antibiotic-associated diarrhea and limits the spr…

This study tests an experimental drug called LMN-201 to see if it can prevent C. difficile infection from coming back after standard antibiotic treatment. About 375 adults with a recent C. diff infection will receive either LMN-201 or a placebo. The main goal is to see if more pe…

This study tests whether taking oral vancomycin alongside other antibiotics can prevent Clostridioides difficile infection (C. diff) in people aged 65 and older. Participants are randomly assigned to receive either vancomycin or standard care. The goal is to see if the drug reduc…

This study tests whether giving patients their own preserved stool (collected before a stem cell transplant) can prevent Clostridium difficile infection afterward. About 59 adults receiving an allogeneic stem cell transplant are randomly assigned to get the stool transplant or st…

This study looks at whether having close contact with pets can help keep your gut healthy while taking antibiotics and lower the risk of a serious infection called C. difficile. Researchers will follow 200 adults getting dental implants who need antibiotics, checking their gut ba…

This study screens adults interested in fecal microbiota transplant (FMT) for Clostridium difficile infection. Researchers will collect medical information and run basic health tests to create a database of potential participants. The goal is to make it faster and easier to enrol…

This study looks at 200 people with known or suspected inflammatory bowel disease (IBD). Researchers will use computers to analyze standard medical images and videos from endoscopies, biopsies, and scans. The goal is to create automated metrics that might help doctors assess IBD …

This study tests a computer tool that uses maps and location data to help infection preventionists find and stop hospital-acquired infections faster. About 25 infection prevention staff will use the tool and report how easy it is to use and whether it helps them respond more quic…

This study is testing a special thermal probe that measures temperature changes in the lining of the colon during a routine colonoscopy. The goal is to see if the probe can detect inflammation in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerati…

This study is collecting health information from 2,000 people with Crohn's disease or ulcerative colitis across three hospitals in South Korea. Researchers aim to build computer models that can predict how each patient will respond to different treatments. No new drugs are being …