Fungal infectious disease

This trial is testing two tuberculosis (TB) vaccines—VPM1002 and a repeat BCG vaccination—in pre-adolescents aged 8-14 who were vaccinated at birth. The goal is to see if these vaccines are safe and trigger a strong immune response in children both with and without HIV, and in th…

This study tests a new vaccine called Candi5V in 251 women who get frequent yeast infections (at least 3 per year). The vaccine is designed to train the body's immune system to fight Candida fungus. Researchers will check if it's safe and if it reduces future infections.

This study tests whether boric acid vaginal inserts (600 mg) taken for 7 or 14 days can safely and effectively treat yeast infections. About 400 women aged 12 and older with active symptoms will participate. The goal is to see if all signs and symptoms disappear without needing m…

This study tests whether adding neuro-athletic training—exercises that challenge the nervous system with extra sensory input—to regular taekwondo practice can improve balance, agility, and jumping ability while reducing injury risk. Researchers will compare two groups of 13 athle…

This study tests a drug called rezafungin for people with a long-term lung infection caused by a fungus (chronic pulmonary aspergillosis) who have few other treatment choices. About 60 adults will receive the drug once a week for 6 months. Researchers will check if the treatment …

This study tests a new home-use LED light device to treat nail fungus (onychomycosis). Researchers want to find the best light dose and how often to use it. Fifty adults with nail fungus will use the device at home and be monitored for improvement.

This study compares a shortened steroid regimen (8 days for moderate, 14 days for severe pneumonia) against the standard 21-day course in 196 HIV patients with Pneumocystis pneumonia. The goal is to see if the shorter treatment is non-inferior in preventing death and complication…

This study tests a topical solution called Trichostatin A for mild-to-severe toenail fungus (onychomycosis). About 50 adults with a confirmed fungal infection will apply the drug daily for 4 weeks. Researchers will check safety and whether the fungus clears up using lab tests.

This study tests a new drug called olorofim against a standard treatment (AmBisome followed by usual care) for a serious lung infection caused by Aspergillus fungus. About 225 adults with proven or probable infection will take part. The main goal is to see if olorofim reduces dea…

This study tests whether a new antifungal drug called rezafungin can prevent serious fungal infections in people who have had a liver transplant. About 385 adults at high risk for infection will receive the drug, and their outcomes will be compared to similar patients from the pa…

This study looks at whether taking beta-alanine, a common supplement, can help wrestlers perform better and feel less muscle fatigue during two days of simulated matches. Sixteen healthy wrestlers aged 12 to 25 will take the supplement and then do wrestling drills to measure thei…

This study tests a product called pHyph for treating thrush (a vaginal yeast infection) in adult women. The goal is to see if pHyph reduces symptoms like itching, burning, and irritation. 48 women will either use pHyph daily for 6 days or receive no treatment, and researchers wil…

This study aims to understand why some women get recurrent vaginal yeast infections (vulvovaginal candidiasis) and others don't. Researchers will compare the vaginal microbiome, immune markers, and metabolic profiles of women with and without the infection. By identifying key dif…

This study looks at HIV-negative people who get opportunistic infections—illnesses that usually only affect those with weak immune systems. Researchers want to find out if these patients have unusual antibodies that block a key immune signal. Up to 224 adults in Thailand and Taiw…

This study explores whether a genetic test (CYP2C19) can help doctors choose the right dose of the antifungal drug voriconazole more quickly. Patients starting voriconazole for an infection will give a blood sample for genotyping. The goal is to see if this personalized dosing re…

This study looks at 120 Canadian women to understand why some get repeated yeast infections while others don't. Researchers will compare the vaginal yeast and bacteria of women with their first infection, those with recurrent infections, and those with yeast but no symptoms. Part…

This study looks at whether vitamin D levels are linked to certain immune markers in people with active tuberculosis (TB), with or without a chronic fungal lung infection called aspergillosis. Researchers will compare blood samples from 300 adults—including healthy volunteers—to …

This study looks at why people with severe liver disease who are in the intensive care unit (ICU) are at risk for a dangerous fungal lung infection called invasive pulmonary aspergillosis. Researchers will study 450 patients to find better ways to predict, diagnose, and treat thi…

This study was designed to learn more about different types of Candida fungus that cause serious bloodstream infections, and how they become resistant to medicines. The researchers planned to study samples from adult patients to track which species were most common and how they r…

This study checks if drinking caffeine changes blood pressure or heart rate in people taking the antifungal medication terbinafine for nail fungus. Researchers will monitor 52 adults before and after they start the drug. The goal is to understand possible side effects, not to tes…

This study looks back at medical records of 150 people treated for mucormycosis, a rare but serious fungal infection. Researchers compare two drugs—amphotericin B and isavuconazole—to see which leads to better survival and fewer side effects. The goal is to help doctors choose th…